VEGFR3/Flt-4 Polyclonal Antibody
- SKU:
- CAB24866
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IF
Description
| Product Name: | VEGFR3/Flt-4 Polyclonal Antibody |
| Product Code: | CAB24866 |
| Reactivity: | Human, Rat |
| Applications: | Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Rat |
| Tested Applications: | IF/ICC |
| Key Applications: | Immunofluorescence |
| Recommended Dilution: | IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Cellular Location: | Cell membrane, Cytoplasm, Nucleus |
Defects in FLT4 are the cause of lymphedema hereditary type 1A (LMPH1A) [MIM:153100]; also known as Nonne-Milroy lymphedema or Milroy disease. Hereditary lymphedema is a chronic disabling condition which results in swelling of the extremities due to altered lymphatic flow. Patients with lymphedema suffer from recurrent local infections and physical impairment. Note=Defects in FLT4 are found in juvenile hemangioma. Juvenile hemangiomas are the most common tumors of infancy, occurring as many as 10% of all births. These benign vascular lesions enlarge rapidly during the first year of life by hyperplasia of endothelial cells and attendant pericytes, and then spontaneously involute over a period of years, leaving loose fibrofatty tissue.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-229 of mouse VEGFR3/Flt-4(NP_032055.1). |
| Sequence: | YSMTP PTLNI TEDSY VIDTG DSLSI SCRGQ HPLEW TWPGA QEVLT TGGKD SEDTR VVHDC EGTEA RPYCK VLLLA QTHAN NTGSY HCYYK YIKAR IEGTT AASTY VFVRD FKHPF INKPD TLLVN RKDSM WVPCL VSIPG LNITL RSQSS ALHPD GQEVL WDDRR GMRVP TQLLR DALYL QCETT WGDQN FLSNL FVVHI TGNEL |
| Synonyms: | flt 4, FLT-4, , VEGF R3, VEGFR 3, VEGFR-3, FLT4, LMPH1A, PCL, Vegfr3 |
| Calculated MW: | 153kDa |
| Observed MW: | Refer to figures |
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