Antibody Name:	VAMP1 Antibody (PACO20848)
Antibody SKU:	PACO20848
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC
Recommended Dilutions:	ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human VAMP1

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20848(VAMP1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).
	Gel: 12%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20848(VAMP1 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds.
	The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20848(VAMP1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.

Synonyms:

vesicle-associated membrane protein 1 (synaptobrevin 1)

UniProt Protein Function:	VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p Cellular Component: cell junction; cell surface; cytosol; integral to plasma membrane; mitochondrial outer membrane; synaptic vesicle membrane; terminal button Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: vesicle fusion Disease: Spastic Ataxia 1, Autosomal Dominant
NCBI Summary:	Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014]
UniProt Code:	P23763
NCBI GenInfo Identifier:	135093
NCBI Gene ID:	6843
NCBI Accession:	P23763.1
UniProt Secondary Accession:	P23763,O75468, Q15857, Q6FG94, Q8IVC9, A8MVP3, D3DUR3
UniProt Related Accession:	P23763
Molecular Weight:	12,658 Da
NCBI Full Name:	Vesicle-associated membrane protein 1
NCBI Synonym Full Names:	vesicle associated membrane protein 1
NCBI Official Symbol:	VAMP1
NCBI Official Synonym Symbols:	SYB1; SPAX1; VAMP-1
NCBI Protein Information:	vesicle-associated membrane protein 1
UniProt Protein Name:	Vesicle-associated membrane protein 1
UniProt Synonym Protein Names:	Synaptobrevin-1
Protein Family:	Vesicle-associated membrane protein
UniProt Gene Name:	VAMP1
UniProt Entry Name:	VAMP1_HUMAN