UTS2B Antibody (PACO20844)
- SKU:
- PACO20844
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UTS2B Antibody (PACO20844) |
| Antibody SKU: | PACO20844 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human UTS2B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-6: A431 cells, Human liver cancer tissue, Lovo cells, PC3 cells, Human placenta tissue, 293T cells,Primary antibody: PACO20844(UTS2B Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20844(UTS2B Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Potent vasoconstrictor.Human Urotensin II is composed of only 11 amino acid, residues, while fish and frog Urotensin II possess 12 and 13 amino acid, residues, respectively (2). Human Urotensin II is found within both vascular and cardiac tissue, including coronary atheroma, and effectively constricts isolated arteries from nonhuman primates (3). Urotensin II may act as an autocrine and/or paracrine hormone rather than as a circulating hormone, by playing an important role in the development of ventricular hypertrophy induced by chronic hypoxia (4). |
| Synonyms: | urotensin 2B |
| UniProt Protein Function: | UTS2D: Potent vasoconstrictor. Belongs to the urotensin-2 family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 3q28 Cellular Component: extracellular region |
| UniProt Code: | Q765I0 |
| NCBI GenInfo Identifier: | 212287929 |
| NCBI Gene ID: | 257313 |
| NCBI Accession: | Q765I0.2 |
| UniProt Secondary Accession: | Q765I0,Q2M1Z2, B3KQY8, D3DNW1, |
| UniProt Related Accession: | Q765I0 |
| Molecular Weight: | 13,749 Da |
| NCBI Full Name: | Urotensin-2B |
| NCBI Synonym Full Names: | urotensin 2B |
| NCBI Official Symbol: | UTS2B |
| NCBI Official Synonym Symbols: | U2B; URP; UTS2D |
| NCBI Protein Information: | urotensin-2B |
| UniProt Protein Name: | Urotensin-2B |
| UniProt Synonym Protein Names: | Urotensin II-related peptide; Urotensin IIB; U-IIB; UIIB; Urotensin-2 domain-containing protein |
| Protein Family: | Prepro-urotensin |
| UniProt Gene Name: | UTS2B |
| UniProt Entry Name: | UTS2B_HUMAN |
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