USP7 Antibody (PACO20830)
- SKU:
- PACO20830
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | USP7 Antibody (PACO20830) |
| Antibody SKU: | PACO20830 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human USP7 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20830(USP7 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Exhibits a preference towards 'Lys-48'-linked Ubiquitin chains. |
| Synonyms: | ubiquitin specific peptidase 7 (herpes virus-associated) |
| UniProt Protein Function: | USP7: an enzyme that removes ubiquitin from its protein substrates. Binds to the herpes virus protein VMW110 that may therefore modulate its substrate specificity or activity to stabilize viral proteins. Regulates MDM2 and has a dynamic role in the p53-MDM2 pathway. Is reported to deubiquitinate and stabilize p53. |
| UniProt Protein Details: | Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 16p13.3 Cellular Component: nuclear body; PML body; cytosol; nucleus Molecular Function:protein C-terminus binding; protein binding; p53 binding; cysteine-type endopeptidase activity; ubiquitin protein ligase binding; ubiquitin-specific protease activity; transcription factor binding Biological Process: proteasomal ubiquitin-dependent protein catabolic process; protein deubiquitination; maintenance of DNA methylation; viral reproduction; regulation of transcription factor activity; inhibition of NF-kappaB transcription factor; transcription-coupled nucleotide-excision repair; multicellular organismal development; histone deubiquitination |
| UniProt Code: | Q93009 |
| NCBI GenInfo Identifier: | 212276477 |
| NCBI Gene ID: | 7874 |
| NCBI Accession: | Q93009.2 |
| UniProt Secondary Accession: | Q93009,A6NMY8, B7Z815, H0Y3G8, |
| UniProt Related Accession: | Q93009 |
| Molecular Weight: | 1102 |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 7 (herpes virus-associated) |
| NCBI Official Symbol: | USP7 |
| NCBI Official Synonym Symbols: | TEF1; HAUSP |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 7; ubiquitin thioesterase 7; deubiquitinating enzyme 7; ubiquitin-specific-processing protease 7; herpesvirus-associated ubiquitin-specific protease; Herpes virus-associated ubiquitin-specific protease; ubiquitin spec |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 7 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7 |
| UniProt Gene Name: | USP7 |
| UniProt Entry Name: | UBP7_HUMAN |
| Antibodies |
| Anti-HAUSP / USP7 Antibody (CAB13564) |
| Anti-USP7 Antibody (CAB13565) |
| Anti-HAUSP / USP7 Antibody (CAB2345) |
| Anti-HAUSP / USP7 Antibody (CAB3448) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Human USP7/HAUSP Recombinant Protein (RPES0289)
system_update_altDatasheetHuman USP7/HAUSP Recombinant Protein Ubiquitin carboxyl-terminal hydrolase 7, also known as Ubiquitin thioesterase 7, Herpesvirus-associated ubiquitin-specific proteas