UNC80 Antibody (PACO50922)
- SKU:
- PACO50922
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UNC80 Antibody (PACO50922) |
| Antibody SKU: | PACO50922 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Protein unc-80 homolog protein (124-388AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO50922 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Western Blot. Positive WB detected in Recombinant protein. All lanes: UNC80 antibody at 3.5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 59 kDa. Observed band size: 59 kDa. |
| Background: | Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium. |
| Synonyms: | Protein unc-80 homolog, UNC80, C2orf21 KIAA1843 |
| UniProt Protein Function: | Component of the NALCN sodium channel complex, required for channel regulation. This complex is a cation channel activated by neuropeptides substance P, neurotensin, and extracellular calcium that regulates neuronal excitability by controlling the sizes of NALCN-dependent sodium-leak current. UNC80 is essential for NALCN sensitivity to extracellular calcium. |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a component of a voltage-independent 'leak' ion-channel complex, in which it performs essential functions, such as serving as a bridge between two other components (sodium leak channel non-selective and UNC79) and as a scaffold for Src kinases. Leak channels play an importnat role in establishment and maintenance of resting membrane potentials in neurons. Mutations in this gene are associated with congenital infantile encephalopathy, intellectual disability and growth issues. [provided by RefSeq, Aug 2016] |
| UniProt Code: | Q8N2C7 |
| NCBI GenInfo Identifier: | 197209826 |
| NCBI Gene ID: | 285175 |
| NCBI Accession: | NP_115893.1 |
| UniProt Secondary Accession: | Q8N2C7,Q96JI4, Q96SS0, B2RN50, B4DQY9, B4DZB3, C4IXS8 C9J1U3 |
| UniProt Related Accession: | Q8N2C7 |
| Molecular Weight: | |
| NCBI Full Name: | protein unc-80 homolog isoform 1 |
| NCBI Synonym Full Names: | unc-80 homolog, NALCN activator |
| NCBI Official Symbol: | UNC80 |
| NCBI Official Synonym Symbols: | UNC-80; C2orf21 |
| NCBI Protein Information: | protein unc-80 homolog |
| UniProt Protein Name: | Protein unc-80 homolog |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein |
| UniProt Gene Name: | UNC80 |
| UniProt Entry Name: | UNC80_HUMAN |
Related Products
Human TP53 antibody(p53 antibody) ELISA Kit
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीक
OSTN Antibody
Overview Product Name:OSTN AntibodyProduct Code:PACO64881Size:50µLTarget Names:OSTNSpecies Reactivity:HumanHost
CYP2A13 Antibody
Overview Product Name:CYP2A13 AntibodyProduct Code:PACO64657Size:50µLTarget Names:CYP2A13Species Reactivity:Human, Mouse
OR13C8 Antibody
Overview Product Name:OR13C8 AntibodyProduct Code:PACO64869Size:50µLTarget Names:OR13C8Species Reactivity:HumanH
TTC14 Antibody
Overview Product Name:TTC14 AntibodyProduct Code:PACO64997Size:50µLTarget Names:TTC14Species Reactivity:HumanHos