Name: UHMK1 Antibody (PACO53882)
SKU: PACO53882
Availability: OutOfStock

Antibody Name:	UHMK1 Antibody (PACO53882)
Antibody SKU:	PACO53882
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA, WB, IHC, IF
Recommended Dilutions:	ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200
Species Reactivity:	Human, Mouse
Immunogen:	Recombinant Human Serine/threonine-protein kinase Kist protein (183-385AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

	Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: UHMK1 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 47, 39, 40 kDa. Observed band size: 47 kDa.
	Immunofluorescent analysis of PC-3 cells using PACO53882 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
	Immunohistochemistry of paraffin-embedded human prostate tissue using PACO53882 at dilution of 1:100.

Background:	Upon serum stimulation, phosphorylates CDKN1B/p27Kip1, thus controlling CDKN1B subcellular location and cell cycle progression in G1 phase. May be involved in trafficking and/or processing of RNA (By similarity).
Synonyms:	Serine/threonine-protein kinase Kist (EC 2.7.11.1) (Kinase interacting with stathmin) (PAM COOH-terminal interactor protein 2) (P-CIP2) (U2AF homology motif kinase 1), UHMK1, KIS KIST

UniProt Protein Function:	KIS: a unique kinase that possesses an RNP type RNA-recognition motif (RRM). A proline-directed kinase with a specificity different from the MAP kinases and CDKs. May be involved in trafficking and/or processing of RNA.Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Other group; Other-Unique familyChromosomal Location of Human Ortholog: 1q23.3Cellular Component: axon; dendrite cytoplasm; nucleusMolecular Function: ATP binding; mRNA binding; protein binding; protein serine/threonine kinase activity; ribonucleoprotein binding; transferase activityBiological Process: cell cycle arrest; mRNA catabolic process, nonsense-mediated decay; neurite development; peptidyl-serine phosphorylation; positive regulation of translational initiation; protein amino acid autophosphorylation; regulation of alternative nuclear mRNA splicing, via spliceosome; regulation of protein export from nucleus
UniProt Protein Details:
NCBI Summary:	The gene encodes a serine/threonine protein kinase that promotes cell cycle progression through G1 by phosphorylation of the cyclin-dependent kinase inhibitor 1B (p27Kip1), which causes nuclear export and degradation. The encoded protein is also thought to function in the adult nervous system and the gene has been associated with schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
UniProt Code:	Q8TAS1
NCBI GenInfo Identifier:	24211880
NCBI Gene ID:	127933
NCBI Accession:	Q8TAS1.2
UniProt Secondary Accession:	Q8TAS1,Q96C22, A0A0A6YYC2, A8K8K4, G3V1M1
UniProt Related Accession:	Q8TAS1
Molecular Weight:	39,044 Da
NCBI Full Name:	Serine/threonine-protein kinase Kist
NCBI Synonym Full Names:	U2AF homology motif (UHM) kinase 1
NCBI Official Symbol:	UHMK1
NCBI Official Synonym Symbols:	KIS; KIST; P-CIP2
NCBI Protein Information:	serine/threonine-protein kinase Kist
UniProt Protein Name:	Serine/threonine-protein kinase Kist
UniProt Synonym Protein Names:	Kinase interacting with stathmin; PAM COOH-terminal interactor protein 2; P-CIP2; U2AF homology motif kinase 1
Protein Family:	Serine/threonine-protein kinase
UniProt Gene Name:	UHMK1
UniProt Entry Name:	UHMK1_HUMAN