UGT1A1 Monoclonal Antibody (CAB22609)
- SKU:
- CAB22609
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | UGT1A1 Monoclonal Antibody |
| Product Code: | CAB22609 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57754 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:2000-1:4000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Hep G2, Mouse liver, Rat liver, |
| Cellular Location: | Endoplasmic reticulum, Endoplasmic reticulum membrane, Microsome, Single-pass membrane protein |
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 101-200 of human UGT1A1 (NP_000454.1). |
| Sequence: | ENDSF LQRVI KTYKK IKKDS AMLLS GCSHL LHNKE LMASL AESSF DVMLT DPFLP CSPIV AQYLS LPTVF FLHAL PCSLE FEATQ CPNPF SYVPR PLSSH |
| Synonyms: | GNT1, UGT1, UDPGT, UGT1A, HUG-BR1, BILIQTL1, UDPGT 1-1 |
| Calculated MW: | 60kDa |
| Observed MW: | 50-60kDa |
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