UFSP2 Antibody (PACO41986)
- SKU:
- PACO41986
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UFSP2 Antibody (PACO41986) |
| Antibody SKU: | PACO41986 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Ufm1-specific protease 2 protein (63-343AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: UFSP2 antibody at 4µg/ml. Lane 1: HepG2 whole cell lysate. Lane 2: NIH/3T3 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 54 kDa. Observed band size: 54 kDa. |
 | Immunofluorescent analysis of Hela cells using PACO41986 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO41986 at dilution of 1:100. |
| Background: | Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. |
| Synonyms: | Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-), UFSP2, C4orf20 |
| UniProt Protein Function: | UFSP2: Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, an ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Belongs to the peptidase C78 family.Protein type: Protease; EC 3.4.22.-Chromosomal Location of Human Ortholog: 4q35.1Cellular Component: endoplasmic reticulum; cytoplasm; nucleusMolecular Function: protein binding; thiolester hydrolase activityBiological Process: regulation of estrogen receptor signaling pathway; proteolysisDisease: Beukes Hip Dysplasia |
| UniProt Protein Details: | |
| NCBI Summary: | Like ubiquitin (see MIM 191339), ubiquitin-fold modifier-1 (UFM1; MIM 610553) must be processed by a protease before it can conjugate with its target proteins. UFSP2 is a thiol protease that specifically processes the C terminus of UFM1 (Kang et al., 2007 [PubMed 17182609]).[supplied by OMIM, Oct 2009] |
| UniProt Code: | Q9NUQ7 |
| NCBI GenInfo Identifier: | 227498137 |
| NCBI Gene ID: | 55325 |
| NCBI Accession: | NP_060829.2 |
| UniProt Secondary Accession: | Q9NUQ7,Q6IA77, Q96FS3 |
| UniProt Related Accession: | Q9NUQ7 |
| Molecular Weight: | 53,261 Da |
| NCBI Full Name: | ufm1-specific protease 2 |
| NCBI Synonym Full Names: | UFM1-specific peptidase 2 |
| NCBI Official Symbol: | UFSP2 |
| NCBI Official Synonym Symbols: | C4orf20 |
| NCBI Protein Information: | ufm1-specific protease 2 |
| UniProt Protein Name: | Ufm1-specific protease 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ufm1-specific protease |
| UniProt Gene Name: | UFSP2 |
| UniProt Entry Name: | UFSP2_HUMAN |
| Antibodies |
| UFSP2 Antibody (PACO13074) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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