Description
| Product Name: | UCP3 Monoclonal Antibody |
| Product Code: | CAB23285 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC60308 |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse skeletal muscle |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.
| Immunogen: | A synthesized peptide derived from human UCP3. |
| Sequence: | MVGLK PSDVP PTMAV KFLGA GTAAC FADLV TFPLD TAKVR LQIQG ENQAV QTARL VQYRG VLGTI LTMVR TEGPC SPYNG LVAGL QRQMS FASIR IGLYD SVKQV YTPKG ADNSS LTTRI LAGCT TGAMA VTCAQ PTDVV KVRFQ ASIHL GPSRS DRKYS GTMDA YRTIA REEGV RGLWK GTLPN IMRNA IVNCA EVVTY DILKE KLLDY HLLTD NFPCH FVSAF GAGFC ATVVA SPVDV VKTRY MNSPP GQYFS PLDCM IKMVA QEGPT AFYKG FTPSF LRLGS WNVVM FVTYE QLKRA LMKVQ MLRES PF |
| Synonyms: | SLC25A9 |
| Calculated MW: | 34kDa |
| Observed MW: | 34kDa |
