UCP1 Monoclonal Antibody
- SKU:
- CAB21979
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | UCP1 Monoclonal Antibody |
| Product Code: | CAB21979 |
| Reactivity: | Mouse |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC54141 |
| Reactivity: | Mouse |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brown adipose |
| Cellular Location: | Mitochondrion inner membrane, Multi-pass membrane protein |
Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human UCP1 (NP_068605.1). |
| Sequence: | QEFLT AGKET APSLG SKILA GLTTG GVAVF IGQPT EVVKV RLQAQ SHLHG IKPRY TGTYN AYRII ATTEG LTGLW KGTTP NLMRS VIINC TELVT YDLMK E |
| Synonyms: | UCP, SLC25A7 |
| Calculated MW: | 33kDa |
| Observed MW: | 30kDa |
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