UCN Antibody (PACO05278)
- SKU:
- PACO05278
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UCN Antibody (PACO05278) |
| Antibody SKU: | PACO05278 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:10000, IHC:1:100-1:300 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from the C-terminal region of human Urocortin. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | UCN; Urocortin |
| UniProt Protein Function: | UCN: Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta. Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 2p23.3 Cellular Component: dendrite; extracellular region; perikaryon; nerve terminal Molecular Function:corticotropin-releasing hormone receptor 1 binding; neuropeptide hormone activity; histone deacetylase inhibitor activity; protein binding; corticotropin-releasing hormone receptor 2 binding Biological Process: regulation of synaptic transmission, glutamatergic; positive regulation of translation; negative regulation of hormone secretion; drinking behavior; response to glucocorticoid stimulus; positive regulation of collagen biosynthetic process; response to pain; negative regulation of cell size; female pregnancy; pancreatic juice secretion; positive regulation of vasodilation; negative regulation of appetite; response to estradiol stimulus; positive regulation of adrenocorticotropic hormone secretion; sensory perception of sound; neuropeptide signaling pathway; positive regulation of cAMP biosynthetic process; negative regulation of blood pressure; inflammatory response; associative learning; neurite development; negative regulation of histone deacetylation; activation of protein kinase A; positive regulation of interleukin-6 production; social behavior; positive regulation of cell growth; positive regulation of peptidyl-serine phosphorylation; positive regulation of vascular permeability; G-protein coupled receptor protein signaling pathway; aerobic respiration; response to oxidative stress; positive regulation of DNA replication; negative regulation of apoptosis |
| NCBI Summary: | This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016] |
| UniProt Code: | P55089 |
| NCBI GenInfo Identifier: | 1718059 |
| NCBI Gene ID: | 7349 |
| NCBI Accession: | P55089.1 |
| UniProt Related Accession: | P55089 |
| Molecular Weight: | |
| NCBI Full Name: | Urocortin |
| NCBI Synonym Full Names: | urocortin |
| NCBI Official Symbol: | UCN |
| NCBI Official Synonym Symbols: | UI; UROC |
| NCBI Protein Information: | urocortin |
| UniProt Protein Name: | Urocortin |
| Protein Family: | Urocortin |
| UniProt Gene Name: | UCN |
| UniProt Entry Name: | UCN1_HUMAN |
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