UBR2 Antibody (PACO37610)
- SKU:
- PACO37610
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UBR2 Antibody (PACO37610) |
| Antibody SKU: | PACO37610 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase UBR2 protein (101-439AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. All lanes: UBR2 antibody at 3µg/ml + Mouse liver tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 201, 50, 67 kDa. Observed band size: 201 kDa. |
| Background: | E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. |
| Synonyms: | E3 ubiquitin-protein ligase UBR2 (EC 2.3.2.27) (N-recognin-2) (RING-type E3 ubiquitin transferase UBR2) (Ubiquitin-protein ligase E3-alpha-2) (Ubiquitin-protein ligase E3-alpha-II), UBR2, C6orf133 KIAA0349 |
| UniProt Protein Function: | UBR2: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Belongs to the UBR1 family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.3.2.-; EC 6.3.2.19; Ubiquitin ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 6p21.1Cellular Component: nucleoplasm; plasma membrane; chromatin; ubiquitin ligase complexMolecular Function: protein binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: ubiquitin-dependent protein catabolic process; negative regulation of TOR signaling pathway; male meiosis I; chromatin silencing; spermatogenesis; histone H2A ubiquitination |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes an E3 ubiquitin ligase of the N-end rule proteolytic pathway that targets proteins with destabilizing N-terminal residues for polyubiquitylation and proteasome-mediated degradation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010] |
| UniProt Code: | Q8IWV8 |
| NCBI GenInfo Identifier: | 73622073 |
| NCBI Gene ID: | 23304 |
| NCBI Accession: | Q8IWV8.1 |
| UniProt Secondary Accession: | Q8IWV8 |
| UniProt Related Accession: | Q8IWV8 |
| Molecular Weight: | |
| NCBI Full Name: | E3 ubiquitin-protein ligase UBR2 |
| NCBI Synonym Full Names: | ubiquitin protein ligase E3 component n-recognin 2 |
| NCBI Official Symbol: | UBR2 |
| NCBI Official Synonym Symbols: | C6orf133; bA49A4.1; dJ242G1.1; dJ392M17.3 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase UBR2 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase UBR2 |
| UniProt Synonym Protein Names: | N-recognin-2; Ubiquitin-protein ligase E3-alpha-2; Ubiquitin-protein ligase E3-alpha-II |
| Protein Family: | E3 ubiquitin-protein ligase |
| UniProt Gene Name: | UBR2 |
| UniProt Entry Name: | UBR2_HUMAN |
| Antibodies |
| UBR2 Antibody (PACO13056) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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