UBE3B Antibody (PACO05660)
- SKU:
- PACO05660
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UBE3B Antibody (PACO05660) |
| Antibody SKU: | PACO05660 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:10000, WB:1:500-1:2000, IHC:1:100-1:300 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from the Internal region of human UBE3B. |
| Form: | Liquid |
| Storage Buffer: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | UBE3B; Ubiquitin-protein ligase E3B |
| UniProt Protein Function: | UBE3B: E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Ligase; EC 6.3.2.19; EC 6.3.2.-; Ubiquitin ligase; Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 12q24.11Molecular Function: ligase activity; ubiquitin-protein ligase activityBiological Process: protein ubiquitination during ubiquitin-dependent protein catabolic processDisease: Kaufman Oculocerebrofacial Syndrome |
| UniProt Protein Details: | |
| NCBI Summary: | The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: E1 ubiquitin-activating enzymes, E2 ubiquitin-conjugating enzymes, and E3 ubiquitin-protein ligases. This gene encodes a member of the E3 ubiquitin-conjugating enzyme family which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme and transfers the ubiquitin to the targeted substrates. A HECT (homology to E6-AP C-terminus) domain in the C-terminus of the longer isoform of this protein is the catalytic site of ubiquitin transfer and forms a complex with E2 conjugases. Shorter isoforms of this protein which lack the C-terminal HECT domain are therefore unlikely to bind E2 enzymes. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2012] |
| UniProt Code: | Q7Z3V4 |
| NCBI GenInfo Identifier: | 296453010 |
| NCBI Gene ID: | 89910 |
| NCBI Accession: | Q7Z3V4.3 |
| UniProt Secondary Accession: | Q7Z3V4,Q05BX9, Q659F7, Q7Z7Q1, Q9BXZ4, A5D8Z3 |
| UniProt Related Accession: | Q7Z3V4 |
| Molecular Weight: | |
| NCBI Full Name: | Ubiquitin-protein ligase E3B |
| NCBI Synonym Full Names: | ubiquitin protein ligase E3B |
| NCBI Official Symbol: | UBE3B |
| NCBI Official Synonym Symbols: | KOS; BPIDS |
| NCBI Protein Information: | ubiquitin-protein ligase E3B |
| UniProt Protein Name: | Ubiquitin-protein ligase E3B |
| UniProt Synonym Protein Names: | |
| Protein Family: | Ubiquitin-protein ligase |
| UniProt Gene Name: | UBE3B |
| UniProt Entry Name: | UBE3B_HUMAN |
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