UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)
![UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58379/63561/ube2s-monoclonal-antibody-pat2n6at-cpab0153__74603__04650.1706534991.jpg?c=1 "UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)")
- SKU:
- CPAB0153
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2a
- Clone:
- PAT2N6AT
- Applications:
- WB
- Applications:
- IF
- Applications:
- ELISA
![UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58379/63561/ube2s-monoclonal-antibody-pat2n6at-cpab0153__74603__04650.1706534991.jpg?c=1&imbypass=on "UBE2S Monoclonal Antibody [PAT2N6AT] (CPAB0153)")
Description
system_update_alt Datasheet
| Product Name: | UBE2S Antibody |
| Product Sku: | CPAB0153 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human UBE2S mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human UBE2S amino acids 1-222 purified from Ecoli. |
| Clone: | PAT2N6AT. |
| Reactivity: | Human |
| Applications: | Western Blot, Immunofluorescence, ELISA |
| Purification Method: | UBE2S antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2a |
| Background: | Ubiquitin-conjugating enzyme E2S (UBE2S) belongs to the ubiquitin-conjugating enzyme family. UBE2S is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a typical property of ubiquitin carrier proteins. UBE2S catalyzes the covalent attachment of ubiquitin to other proteins. UBE2S acts as a crucial factor of the anaphase promoting complex/cyclosome (APC/C), which is a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. UBE2S acts by purposely elongating ''Lys-11''-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, augmenting the degradation of APC/C substrates by the proteasome and promoting mitotic exit. UBE2S also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is nevertheless uncertain whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. UBE2S is also involved in ubiquitination and consequent degradation of VHL, resu |
| Synonyms: | Ubiquitin-conjugating enzyme E2 S, Ubiquitin-protein ligase S, Ubiquitin carrier protein S, Ubiquitin-conjugating enzyme E2-24 kDa, E2-EPF5, E2-EPF, UBE2S, E2EPF, EPF5. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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