UBASH3A Antibody (PACO22637)
- SKU:
- PACO22637
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | UBASH3A Antibody (PACO22637) |
| Antibody SKU: | PACO22637 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human |
| Immunogen: | Synthesized peptide derived from internal of human UBASH3A. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from LOVO cells, HuvEc cells and K562 cells, using UBASH3A antibody. |
| Background: | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. |
| Synonyms: | Suppressor of T-cell receptor signaling 2; STS-2; Cbl-interacting protein 4; CLIP4; T-cell ubiquitin ligand |
| UniProt Protein Function: | STS2: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors, EGFR and PDGFRB, on the cell surface. Exhibits negligigle protein tyrosine phosphatase activity at neutral pH. May act as a dominant-negative regulator of UBASH3B-dependent dephosphorylation. May inhibit dynamin-dependent endocytic pathways by functionally sequestering dynamin via its SH3 domain. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein phosphatase, tyrosine (non-receptor)Chromosomal Location of Human Ortholog: 21q22.3Cellular Component: cytosolMolecular Function: protein binding |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011] |
| UniProt Code: | P57075 |
| NCBI GenInfo Identifier: | 10720330 |
| NCBI Gene ID: | 53347 |
| NCBI Accession: | P57075.1 |
| UniProt Secondary Accession: | P57075,Q6HA34, Q6HA35, Q6ISI6, Q6ISK3, Q6ISS9, G5E9E4 |
| UniProt Related Accession: | P57075 |
| Molecular Weight: | 59,167 Da |
| NCBI Full Name: | Ubiquitin-associated and SH3 domain-containing protein A |
| NCBI Synonym Full Names: | ubiquitin associated and SH3 domain containing A |
| NCBI Official Symbol: | UBASH3A |
| NCBI Official Synonym Symbols: | TULA; CLIP4; STS-2; TULA-1 |
| NCBI Protein Information: | ubiquitin-associated and SH3 domain-containing protein A |
| UniProt Protein Name: | Ubiquitin-associated and SH3 domain-containing protein A |
| UniProt Synonym Protein Names: | Cbl-interacting protein 4; CLIP4; Suppressor of T-cell receptor signaling 2; STS-2; T-cell ubiquitin ligand 1; TULA-1 |
| Protein Family: | Ubiquitin-associated and SH3 domain-containing protein |
| UniProt Gene Name: | UBASH3A |
| UniProt Entry Name: | UBS3A_HUMAN |
| Antibodies |
| UBASH3A Antibody (PACO04601) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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