Tyrosinase Monoclonal Antibody (CAB23209)
- SKU:
- CAB23209
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | Tyrosinase Monoclonal Antibody |
| Product Code: | CAB23209 |
| Reactivity: | Human |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53165 |
| Reactivity: | Human |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Melanosome membrane, Single-pass type I membrane protein |
The enzyme encoded by this gene catalyzes the first 2 steps, and at least 1 subsequent step, in the conversion of tyrosine to melanin. The enzyme has both tyrosine hydroxylase and dopa oxidase catalytic activities, and requires copper for function. Mutations in this gene result in oculocutaneous albinism, and nonpathologic polymorphisms result in skin pigmentation variation. The human genome contains a pseudogene similar to the 3' half of this gene.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human Tyrosinase (NP_000363.1). |
| Sequence: | FAHEA PAFLP WHRLF LLRWE QEIQK LTGDE NFTIP YWDWR DAEKC DICTD EYMGG QHPTN PNLLS PASFF SSWQI VCSRL EEYNS HQSLC NGTPE GPLRR N |
| Synonyms: | ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 |
| Calculated MW: | 60kDa |
| Observed MW: | Refer to figures |
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