Antibody Name:	Txnip Antibody (PACO37578)
Antibody SKU:	PACO37578
Size:	50ug
Host Species:	Rabbit
Tested Applications:	ELISA
Recommended Dilutions:
Species Reactivity:	Mouse
Immunogen:	Recombinant Mouse Thioredoxin-interacting protein (1-397AA)

Form:	Liquid
Storage Buffer:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Purification Method:	>95%, Protein G purified
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

Background:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth.

Synonyms:

Thioredoxin-interacting protein (Vitamin D3 up-regulated protein 1), Txnip, Vdup1

UniProt Protein Function:	TXNIP: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over- expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Belongs to the arrestin family.Protein type: Apoptosis; Mitochondrial; Motility/polarity/chemotaxis; Tumor suppressorChromosomal Location of Human Ortholog: 3 F2.1\|3 41.93 cMCellular Component: cytoplasm; mitochondrial intermembrane space; nucleusMolecular Function: enzyme inhibitor activity; protein binding; ubiquitin protein ligase bindingBiological Process: cell cycle; keratinocyte differentiation; negative regulation of cell division; negative regulation of transcription from RNA polymerase II promoter; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; protein import into nucleus; regulation of cell proliferation; regulation of transcription, DNA-templated; response to oxidative stress; transcription, DNA-dependent
UniProt Protein Details:
NCBI Summary:
UniProt Code:	Q8BG60
NCBI GenInfo Identifier:	60687518
NCBI Gene ID:	56338
NCBI Accession:	NP_001009935.1
UniProt Secondary Accession:	Q8BG60,Q8BGQ0, Q8K2B2, Q9DC00, Q9EP90, Q9R115
UniProt Related Accession:	Q8BG60
Molecular Weight:	44,292 Da
NCBI Full Name:	thioredoxin-interacting protein isoform 1
NCBI Synonym Full Names:	thioredoxin interacting protein
NCBI Official Symbol:	Txnip
NCBI Official Synonym Symbols:	THIF; Tbp-2; VDUP1; Hyplip1; AA682105; 1200008J08Rik
NCBI Protein Information:	thioredoxin-interacting protein
UniProt Protein Name:	Thioredoxin-interacting protein
UniProt Synonym Protein Names:	Vitamin D3 up-regulated protein 1
Protein Family:	TATA-binding protein
UniProt Gene Name:	Txnip
UniProt Entry Name: