Name: TXNIP Antibody (PACO20800)
SKU: PACO20800
Availability: OutOfStock

Antibody Name:	TXNIP Antibody (PACO20800)
Antibody SKU:	PACO20800
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide of human TXNIP

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20800(TXNIP Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: x200).

Background:

May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).

Synonyms:

thioredoxin interacting protein

UniProt Protein Function:	May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).
NCBI Summary:	This gene encodes a thioredoxin-binding protein that is a member of the alpha arrestin protein family. Thioredoxin is a thiol-oxidoreductase that is a major regulator of cellular redox signaling which protects cells from oxidative stress. This protein inhibits the antioxidative function of thioredoxin resulting in the accumulation of reactive oxygen species and cellular stress. This protein also functions as a regulator of cellular metabolism and of endoplasmic reticulum (ER) stress. This protein may also function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
UniProt Code:	Q9H3M7
NCBI GenInfo Identifier:	928192549
NCBI Gene ID:	10628
NCBI Accession:	NP_001300901.1
UniProt Secondary Accession:	Q9H3M7,Q16226, Q6PML0, Q9BXG9, B4E3D3,
UniProt Related Accession:	Q9H3M7
Molecular Weight:	37,319 Da
NCBI Full Name:	thioredoxin-interacting protein isoform 2
NCBI Synonym Full Names:	thioredoxin interacting protein
NCBI Official Symbol:	TXNIP
NCBI Official Synonym Symbols:	THIF; VDUP1; ARRDC6; HHCPA78; EST01027
NCBI Protein Information:	thioredoxin-interacting protein
UniProt Protein Name:	Thioredoxin-interacting protein
UniProt Synonym Protein Names:	Thioredoxin-binding protein 2; Vitamin D3 up-regulated protein 1
Protein Family:	TATA-binding protein
UniProt Gene Name:	TXNIP

Antibodies	ELISA Kits
Anti-TXNIP Antibody (CAB9342)	Human TXNIP / Thioredoxin-interacting protein ELISA Kit
	Human Thioredoxin-interacting protein (TXNIP) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)