TXN2 Monoclonal Antibody [PAT1B1AT] (CPAB0667)
![TXN2 Monoclonal Antibody [PAT1B1AT] (CPAB0667)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/608x608/products/58887/64069/assay-genie-box-4__42476.1706535249.jpg?c=1 "TXN2 Monoclonal Antibody [PAT1B1AT] (CPAB0667)")
- SKU:
- CPAB0667
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Universal
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- PAT1B1AT
- Applications:
- ELISA
- Applications:
- FC
![TXN2 Monoclonal Antibody [PAT1B1AT] (CPAB0667)](https://cdn11.bigcommerce.com/s-rd6ounxcu2/images/stencil/1280x1280/products/58887/64069/assay-genie-box-4__42476.1706535249.jpg?c=1&imbypass=on "TXN2 Monoclonal Antibody [PAT1B1AT] (CPAB0667)")
Description
system_update_alt Datasheet
| Product Name: | TXN2 Antibody |
| Product Sku: | CPAB0667 |
| Size: | 5μg |
| Host Species: | Mouse |
| Immunogen: | Anti-human TXN2 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human TXN2 protein 6-166 amino acids purified from Ecoli. |
| Clone: | PAT1B1AT. |
| Reactivity: | Other bodies |
| Applications: | ELISA, Flow Cytometry |
| Purification Method: | TXN2 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography. |
| Isotype: | IgG2b |
| Background: | Thioredoxin-2 is a low molecular weight redox protein. TRX2 contains a redox active disulfide/dithiol group within the conserved Cys-Gly-Pro-Cys active site. The TXN2 is involved in the regulation of the mitochondrial membrane potential and in protection against oxidant-induced apoptosis. Upon stimulation of Fas, TXN2 mediates denitrosylation of mitochondria-associated caspase-3, a process required for caspase-3 activation, and promoted apoptosis. TRX2 is important at low oxidative stress conditions. MTRX is involved in the regulation of the mitochondrial membrane potential and cell death. Mitochondrial thioredoxin plays an important roles in protection against oxidant-induced apoptosis. Thioredoxin1 and thioredoxin2 have opposed regulatory functions on hypoxia-inducible factor-1alpha. |
| Synonyms: | Thioredoxin mitochondrial, Thioredoxin-2, TXN2, MTRX, TRX2, MT-TRX, TRX-2, TXN-2. |
| Storage Buffer: | For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles. |
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