Twist Polyclonal Antibody
- SKU:
- CAB5526
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
| Product Name: | Twist Polyclonal Antibody |
| Product Code: | CAB5526 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, ELISA |
| Key Applications: | Immunohistochemistry |
| Recommended Dilution: | IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | HL-60 |
| Cellular Location: | Nucleus |
This gene encodes a basic helix-loop-helix (bHLH) transcription factor that plays an important role in embryonic development. The encoded protein forms both homodimers and heterodimers that bind to DNA E box sequences and regulate the transcription of genes involved in cranial suture closure during skull development. This protein may also regulate neural tube closure, limb development and brown fat metabolism. This gene is hypermethylated and overexpressed in multiple human cancers, and the encoded protein promotes tumor cell invasion and metastasis, as well as metastatic recurrence. Mutations in this gene cause Saethre-Chotzen syndrome in human patients, which is characterized by craniosynostosis, ptosis and hypertelorism.
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 51-150 of human Twist (NP_000465.1). |
| Sequence: | GPGGA AGGGV GGGDE PGSPA QGKRG KKSAG CGGGG GAGGG GGSSS GGGSP QSYEE LQTQR VMANV RERQR TQSLN EAFAA LRKII PTLPS DKLSK IQTLK |
| Synonyms: | CRS, CSO, SCS, ACS3, CRS1, BPES2, BPES3, SWCOS, TWIST, bHLHa38 |
| Calculated MW: | 21kDa |
| Observed MW: | 30kDa |
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