Tumor Necrosis Factor-a monoclonal antibody (PE) (AGIM0381)
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- SKU:
- AGIM0381
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Host Species:
- Mouse
- Isotype:
- IgG2b
- Clone:
- IT-5H2
- Conjugation:
- PE
- Applications:
- FC
Description
system_update_altDatasheet
| Product Name: | Tumor Necrosis Factor-a monoclonal antibody (PE) |
| Product Code: | AGIM0381 |
| Size: | 100 µL |
| Reactivity: | Human |
| Clone: | IT-5H2 |
| Applications: | Flow Cytometry |
| Conjugate: | PE |
| Isotype: | IgG2b |
| Host Species: | Mouse |
| Storage: | Store at 4°C. Avoid prolonged exposure to light. |
| Uniprot: | P24043 |
| Background: | TNF-alpha is a cytokine produced by monocytes, macrophages, neutrophils, NK cells, CD4+ T cells and many transformed cells. It can be expressed as a 17 kDa free molecule, or as a 26 kDa membrane protein. TNF-alpha easily forms stable trimers, but also other multimeric complexes. In the immune system, it is an important regulator, which has cytolytic and cytostatic activity against a range of tumor cells, increases fibroblast proliferation and supports neutrophil chemotaxis and phagocytosis. |
| UniProt Protein Function: | Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. |
| UniProt Protein Details: | |
| NCBI Summary: | Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P24043 |
| NCBI GenInfo Identifier: | 28559088 |
| NCBI Gene ID: | 3908 |
| NCBI Accession: | NP_000417.2 |
| UniProt Secondary Accession: | P24043,Q14736, Q5VUM2, Q93022 |
| UniProt Related Accession: | P24043 |
| Molecular Weight: | |
| NCBI Full Name: | laminin subunit alpha-2 isoform a |
| NCBI Synonym Full Names: | laminin subunit alpha 2 |
| NCBI Official Symbol: | LAMA2 |
| NCBI Official Synonym Symbols: | LAMM |
| NCBI Protein Information: | laminin subunit alpha-2 |
| UniProt Protein Name: | Laminin subunit alpha-2 |
| UniProt Synonym Protein Names: | Laminin M chain; Laminin-12 subunit alpha; Laminin-2 subunit alpha; Laminin-4 subunit alpha; Merosin heavy chain |
| Protein Family: | Laminin |
| UniProt Gene Name: | LAMA2 |
| UniProt Entry Name: |
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