TULP3 Antibody (PACO30900)
- SKU:
- PACO30900
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TULP3 Antibody (PACO30900) |
| Antibody SKU: | PACO30900 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tubby-related protein 3 protein (1-260AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO30900 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO30900 at dilution of 1:100. |
| Background: | Negative regulator of the Shh signaling transduction pathway: recruited to primary cilia via association with the IFT complex A (IFT-A) and is required for recruitment of G protein-coupled receptor GPR161 to cilia, a promoter of PKA-dependent basal repression machinery in Shh signaling. Binds to phosphorylated inositide (phosphoinositide) lipids. Both IFT-A- and phosphoinositide-binding properties are required to regulate ciliary G protein-coupled receptor trafficking. Not involved in ciliogenesis. |
| Synonyms: | Tubby-related protein 3 (Tubby-like protein 3), TULP3, TUBL3 |
| UniProt Protein Function: | TULP3: Negatively regulates SHH signal transduction. Probably functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to phosphorylated inositide lipids. Belongs to the TUB family.Chromosomal Location of Human Ortholog: 12p13.3Cellular Component: cilium; nucleolus; nucleus; plasma membraneMolecular Function: enzyme binding; phosphoinositide binding; protein binding; protein complex bindingBiological Process: negative regulation of smoothened signaling pathway; regulation of G-protein coupled receptor protein signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a member of the tubby gene family of bipartite transcription factors. Members of this family have been identified in plants, vertebrates, and invertebrates, and they share a conserved N-terminal transcription activation region and a conserved C-terminal DNA and phosphatidylinositol-phosphate binding region. The encoded protein binds to phosphoinositides in the plasma membrane via its C-terminal region and probably functions as a membrane-bound transcription regulator that translocates to the nucleus in response to phosphoinositide hydrolysis, for instance, induced by G-protein-coupled-receptor signaling. It plays an important role in neuronal development and function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, May 2009] |
| UniProt Code: | O75386 |
| NCBI GenInfo Identifier: | 125987867 |
| NCBI Gene ID: | 7289 |
| NCBI Accession: | O75386.2 |
| UniProt Secondary Accession: | O75386,Q8N5B0, B3KNB7, B7Z6A2, D3DUQ4, F8WBZ9 |
| UniProt Related Accession: | O75386 |
| Molecular Weight: | 19,273 Da |
| NCBI Full Name: | Tubby-related protein 3 |
| NCBI Synonym Full Names: | tubby like protein 3 |
| NCBI Official Symbol: | TULP3 |
| NCBI Official Synonym Symbols: | TUBL3 |
| NCBI Protein Information: | tubby-related protein 3 |
| UniProt Protein Name: | Tubby-related protein 3 |
| UniProt Synonym Protein Names: | Tubby-like protein 3 |
| Protein Family: | Tubby-related protein |
| UniProt Gene Name: | TULP3 |
| UniProt Entry Name: | TULP3_HUMAN |
| Antibodies |
| TULP3 Antibody (PACO12992) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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