TTLL6 Antibody (PACO37950)
- SKU:
- PACO37950
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TTLL6 Antibody (PACO37950) |
| Antibody SKU: | PACO37950 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Tubulin polyglutamylase TTLL6 protein (121-310AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: U87 whole cell lysate. All lanes: TTLL6 antibody at 5µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 97, 65 kDa. Observed band size: 97 kDa. |
 | IHC image of PACO37950 diluted at 1:500 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. |
| Synonyms: | Tubulin polyglutamylase TTLL6 (EC 6.-.-.-) (Tubulin--tyrosine ligase-like protein 6), TTLL6, TTL.6 |
| UniProt Protein Function: | Polyglutamylase which preferentially modifies alpha-tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA-binding activity of CGAS. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8N841 |
| NCBI GenInfo Identifier: | 195963418 |
| NCBI Gene ID: | 284076 |
| NCBI Accession: | NP_001124390.1 |
| UniProt Secondary Accession: | Q8N841,Q24KB1, Q24KB2, Q24KB6, Q24KF3, Q24KJ5, Q24KN7 Q24KS9, Q24KX1, Q24L13 |
| UniProt Related Accession: | Q8N841 |
| Molecular Weight: | Observed: 43-45 kDaPredicted: 97 kDa |
| NCBI Full Name: | tubulin polyglutamylase TTLL6 isoform 1 |
| NCBI Synonym Full Names: | tubulin tyrosine ligase like 6 |
| NCBI Official Symbol: | TTLL6 |
| NCBI Official Synonym Symbols: | TTL.6 |
| NCBI Protein Information: | tubulin polyglutamylase TTLL6 |
| UniProt Protein Name: | Tubulin polyglutamylase TTLL6 |
| UniProt Synonym Protein Names: | Tubulin--tyrosine ligase-like protein 6 |
| Protein Family: | TITAN-like protein |
| UniProt Gene Name: | TTLL6 |
| UniProt Entry Name: |
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