TTI2 Antibody (PACO60176)
- SKU:
- PACO60176
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TTI2 Antibody (PACO60176) |
| Antibody SKU: | PACO60176 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:20-1:200 |
| Species Reactivity: | Human, Rat |
| Immunogen: | Recombinant Human TELO2-interacting protein 2 protein (159-264AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate, HepG2 whole cell lysate, PC-3 whole cell lysate, Rat kidney tissue. All lanes: TTI2 antibody at 8.7µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa. |
 | IHC image of PACO60176 diluted at 1:100 and staining in paraffin-embedded human adrenal gland tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO60176 diluted at 1:100 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. |
| Synonyms: | TELO2-interacting protein 2, TTI2, C8orf41 |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013] |
| UniProt Code: | Q6NXR4 |
| NCBI GenInfo Identifier: | 156151411 |
| NCBI Gene ID: | 80185 |
| NCBI Accession: | NP_001095871.1 |
| UniProt Secondary Accession: | Q6NXR4 |
| UniProt Related Accession: | Q6NXR4 |
| Molecular Weight: | 56 kDa |
| NCBI Full Name: | TELO2-interacting protein 2 isoform 1 |
| NCBI Synonym Full Names: | TELO2 interacting protein 2 |
| NCBI Official Symbol: | TTI2 |
| NCBI Official Synonym Symbols: | MRT39; C8orf41 |
| NCBI Protein Information: | TELO2-interacting protein 2 |
| UniProt Protein Name: | TELO2-interacting protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | TEL2-interacting protein |
| UniProt Gene Name: | TTI2 |
| UniProt Entry Name: | TTI2_HUMAN |
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