TTI1 Antibody (PACO20787)
- SKU:
- PACO20787
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TTI1 Antibody (PACO20787) |
| Antibody SKU: | PACO20787 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human TTI1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20787(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20787(TTI1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. |
| Synonyms: | TELO2 interacting protein 1 |
| UniProt Protein Function: | Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. Promotes assembly, stabilizes and maintains the activity of mTORC1 and mTORC2 complexes, which regulate cell growth and survival in response to nutrient and hormonal signals. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O43156 |
| NCBI GenInfo Identifier: | 743405613 |
| NCBI Gene ID: | 9675 |
| NCBI Accession: | |
| UniProt Secondary Accession: | O43156,Q5JX67, Q96A38, Q9BR47, Q9H4K0, D6W4K3 |
| UniProt Related Accession: | O43156 |
| Molecular Weight: | 122,069 Da |
| NCBI Full Name: | TELO2-interacting protein 1 homolog |
| NCBI Synonym Full Names: | TELO2 interacting protein 1 |
| NCBI Official Symbol: | TTI1 |
| NCBI Official Synonym Symbols: | smg-10; KIAA0406 |
| NCBI Protein Information: | TELO2-interacting protein 1 homolog |
| UniProt Protein Name: | TELO2-interacting protein 1 homolog |
| UniProt Synonym Protein Names: | Protein SMG10 |
| Protein Family: | TEL2-interacting protein |
| UniProt Gene Name: | TTI1 |
| UniProt Entry Name: | TTI1_HUMAN |
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