TTBK1 Antibody (PACO20783)
- SKU:
- PACO20783
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TTBK1 Antibody (PACO20783) |
| Antibody SKU: | PACO20783 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human TTBK1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20783(TTBK1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using PACO20783(TTBK1 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | TTBK1 (tau tubulin kinase 1), also known as BDTK (brain-derived tau kinase), is a 1,321 amino acid, protein that contains one protein kinase domain and belongs to the serine/threonine protein kinase family. Localized to the cytoplasm and expressed at high levels in brain and at lower levels in testis and spinal cord, TTBK1 functions as a serine/threonine kinase that can phosphorylate Tau (a protein involved in tubulin polymerization) on threonine, tyrosine and serine residues. Specifically, TTBK1 uses divalent cations, such as magnesium and manganese, to catalyze the ATP-dependent transfer of a phosphate group onto Tau, creating a phosphoprotein and ADP. Phosphorylation of Tau causes its aggregation and subsequent loss of function, suggesting an important role for TTBK1 in the control of tubulin dynamics. |
| Synonyms: | tau tubulin kinase 1 |
| UniProt Protein Function: | TTBK1: Serine/threonine kinase which is able to phosphorylate TAU on serine, threonine and tyrosine residues. Induces aggregation of TAU. Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.1; Protein kinase, CK1; CK1 group; TTBK familyChromosomal Location of Human Ortholog: 6p21.1Cellular Component: cytoplasm; nucleusMolecular Function: protein serine/threonine kinase activity; ATP bindingBiological Process: regulation of cell shape; peptidyl-serine phosphorylation; substantia nigra development |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q5TCY1 |
| NCBI GenInfo Identifier: | 97203020 |
| NCBI Gene ID: | 84630 |
| NCBI Accession: | Q5TCY1.2 |
| UniProt Secondary Accession: | Q5TCY1,Q2L6C6, Q6ZNH0, Q8N444, Q96JH2, A2A2U5 |
| UniProt Related Accession: | Q5TCY1 |
| Molecular Weight: | 69,084 Da |
| NCBI Full Name: | Tau-tubulin kinase 1 |
| NCBI Synonym Full Names: | tau tubulin kinase 1 |
| NCBI Official Symbol: | TTBK1 |
| NCBI Official Synonym Symbols: | BDTK |
| NCBI Protein Information: | tau-tubulin kinase 1; brain-derived tau kinase |
| UniProt Protein Name: | Tau-tubulin kinase 1 |
| UniProt Synonym Protein Names: | Brain-derived tau kinase |
| Protein Family: | Tau-tubulin kinase |
| UniProt Gene Name: | TTBK1 |
| UniProt Entry Name: | TTBK1_HUMAN |
Related Products
SPEF2 Antibody
Overview Product Name:SPEF2 AntibodyProduct Code:PACO64977Size:50µLTarget Names:SPEF2Species Reactivity:HumanHos
ompF Antibody
Overview Product Name:ompF AntibodyProduct Code:PACO64865Size:50µLTarget Names:ompFSpecies Reactivity:Escherichia coli
Hmgb1 Antibody
Overview Product Name:Hmgb1 AntibodyProduct Code:PACO64769Size:50µLTarget Names:Hmgb1Species Reactivity:RatHost
RIMS4 Antibody
Overview Product Name:RIMS4 AntibodyProduct Code:PACO64925Size:50µLTarget Names:RIMS4Species Reactivity:HumanHos
C22orf39 Antibody
Overview Product Name:C22orf39 AntibodyProduct Code:PACO64621Size:50µLTarget Names:C22orf39Species Reactivity:Human<