TSPAN12 Antibody (PACO12958)
- SKU:
- PACO12958
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TSPAN12 Antibody (PACO12958) |
| Antibody SKU: | PACO12958 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TSPAN12 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | tetraspanin 12;TSPAN12;NET-2;TM4SF12 ; |
| UniProt Protein Function: | TSPAN12: a multi-pass membrane protein. Member of the transmembrane 4 superfamily, also known as the tetraspanin family. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP-dependent cleavage activity. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5 (EVR5). It is a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina. Twp isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Receptor, misc.; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7q31.31 Cellular Component: membrane; integral to plasma membrane; integral to membrane Molecular Function:Wnt receptor activity Biological Process: cell surface receptor linked signal transduction; angiogenesis; regulation of angiogenesis Disease: Exudative Vitreoretinopathy 5 |
| UniProt Code: | O95859 |
| NCBI GenInfo Identifier: | 11135167 |
| NCBI Gene ID: | |
| NCBI Accession: | O95859.1 |
| Molecular Weight: | Observed MW: 35kDa |
| NCBI Full Name: | Tetraspanin-12 |
| UniProt Protein Name: | Tetraspanin-12 |
| UniProt Synonym Protein Names: | Tetraspan NET-2; Transmembrane 4 superfamily member 12 |
| UniProt Gene Name: | TSPAN12 |
| UniProt Entry Name: | TSN12_HUMAN |
Related Products
Human TSPAN12 (Tetraspanin-12) ELISA Kit (HUFI05913)
system_update_altDatasheet - तकनीकी मैनुअलsystem_update_altMSDS - तकनीकी
SIM1 Antibody
Overview Product Name:SIM1 AntibodyProduct Code:PACO64949Size:50µLTarget Names:SIM1Species Reactivity:HumanHost
eutC Antibody
Overview Product Name:eutC AntibodyProduct Code:PACO64709Size:50µLTarget Names:eutCSpecies Reactivity:Escherichia coli
EPHA10 Antibody
Overview Product Name:EPHA10 AntibodyProduct Code:PACO64693Size:50µLTarget Names:EPHA10Species Reactivity:HumanH