TSHZ1 Antibody (PACO12955)
- SKU:
- PACO12955
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TSHZ1 Antibody (PACO12955) |
| Antibody SKU: | PACO12955 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TSHZ1 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | teashirt zinc finger homeobox 1;TSHZ1;NY-CO-33;SDCCAG33;TSH1 ; |
| UniProt Protein Function: | TSHZ1: Probable transcriptional regulator involved in developmental processes. May act as a transcriptional repressor (Potential). Defects in TSHZ1 are the cause of congenital aural atresia (CAA). A rare anomaly of the ear that involves some degree of failure of the development of the external auditory canal. The malformation can also involve the tympanic membrane, ossicles and middle ear space. The inner ear development is most often normal. Different CAA forms are known. CAA type I is characterized by bony or fibrous atresia of the lateral part of the external auditory canal and an almost normal medial part and middle ear. CAA type II is the most frequent type and is characterized by partial or total aplasia of the external auditory canal. CAA type IIA involves an external auditory canal with either complete bony atresia of the medial part or partial aplasia that ends blindly in a fistula leading to a rudimentary tympanic membrane. CAA type IIB is characterized by bony stenosis of the total length of the external auditory canal. CAA type III involves bony atresia of the external auditory canal and a very small or absent middle-ear cavity. Belongs to the teashirt C2H2-type zinc-finger protein family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: C2H2-type zinc finger protein; Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 18q22.3Disease: Aural Atresia, Congenital |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a colon cancer antigen that was defined by serological analysis of recombinant cDNA expression libraries. The encoded protein is a member of the teashirt C2H2-type zinc-finger protein family and may be involved in transcriptional regulation of developmental processes. Mutations in this gene may be associated with congenital aural atresia syndrome. [provided by RefSeq, Jan 2012] |
| UniProt Code: | Q6ZSZ6 |
| NCBI GenInfo Identifier: | 85683261 |
| NCBI Gene ID: | 10194 |
| NCBI Accession: | Q6ZSZ6.2 |
| UniProt Secondary Accession: | Q6ZSZ6,O60534, Q4LE29, Q53EU4 |
| UniProt Related Accession: | Q6ZSZ6 |
| Molecular Weight: | 112,705 Da |
| NCBI Full Name: | Teashirt homolog 1 |
| NCBI Synonym Full Names: | teashirt zinc finger homeobox 1 |
| NCBI Official Symbol: | TSHZ1 |
| NCBI Official Synonym Symbols: | CAA; TSH1; NY-CO-33; SDCCAG33 |
| NCBI Protein Information: | teashirt homolog 1 |
| UniProt Protein Name: | Teashirt homolog 1 |
| UniProt Synonym Protein Names: | Antigen NY-CO-33; Serologically defined colon cancer antigen 33 |
| Protein Family: | Teashirt |
| UniProt Gene Name: | TSHZ1 |
| UniProt Entry Name: | TSH1_HUMAN |
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