TRO Antibody (PACO62391)
- SKU:
- PACO62391
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TRO Antibody (PACO62391) |
| Antibody SKU: | PACO62391 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Trophinin protein (1-164AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of Hela cells with PACO62391 at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. |
| Synonyms: | Trophinin (MAGE-D3 antigen), TRO, KIAA1114 MAGED3 |
| UniProt Protein Function: | TRO: Could be involved with bystin and tastin in a cell adhesion molecule complex that mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of the embryo implantation. Directly responsible for homophilic cell adhesion. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Cell adhesionChromosomal Location of Human Ortholog: Xp11.22-p11.21Cellular Component: cytoplasm; integral to plasma membrane; nucleus; plasma membraneMolecular Function: protein bindingBiological Process: embryo implantation; homophilic cell adhesion; negative regulation of cell growth |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a membrane protein that mediates cell adhesion between trophoblastic cells and the epithelial cells of the endometrium. The encoded protein participates in cell signalling during embryo implantation, and may also be involved in cancer formation. This gene is located near several other closely related genes on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012] |
| UniProt Code: | Q12816 |
| NCBI GenInfo Identifier: | 89276766 |
| NCBI Gene ID: | 7216 |
| NCBI Accession: | NP_001034794 |
| UniProt Secondary Accession: | Q12816,Q96SX2, Q9NU89, Q9UPN8, B1AKE9, B1AKF1, F5GY27 |
| UniProt Related Accession: | Q12816 |
| Molecular Weight: | Predicted: 78, 157 kDaObserved: 94 kDa |
| NCBI Full Name: | trophinin isoform 5 |
| NCBI Synonym Full Names: | trophinin |
| NCBI Official Symbol: | TRO |
| NCBI Official Synonym Symbols: | MAGED3; MAGE-d3 |
| NCBI Protein Information: | trophinin |
| UniProt Protein Name: | Trophinin |
| UniProt Synonym Protein Names: | MAGE-D3 antigen |
| Protein Family: | Trophinin |
| UniProt Gene Name: | TRO |
| UniProt Entry Name: | TROP_HUMAN |
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