Name: TRIP6 Antibody (PACO17320)
SKU: PACO17320
Availability: OutOfStock

Antibody Name:	TRIP6 Antibody (PACO17320)
Antibody SKU:	PACO17320
Size:	50ul
Host Species:	Rabbit
Tested Applications:	ELISA, IHC
Recommended Dilutions:	ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:	Human, Mouse
Immunogen:	Fusion protein of human TRIP6

Form:	Liquid
Storage Buffer:	-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:	Antigen affinity purification
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Non-conjugated

The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17320(TRIP6 Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: x200).

Background:

This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid, (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.

Synonyms:

thyroid hormone receptor interactor 6

UniProt Protein Function:	TRIP6: thyroid receptor interacting protein 6 specifically interacts with the ligand-binding domain of the thyroid receptor (TR). Requires the presence of thyroid hormone for its interaction. Interacts with PTPN13. Functions downstream of the activated LPA(2) receptor and is involved in cell adhesion and migration.Protein type: Nuclear receptor co-regulator; Motility/polarity/chemotaxis; Adaptor/scaffoldChromosomal Location of Human Ortholog: 7q22Cellular Component: interleukin-1 receptor complex; cytoskeleton; focal adhesion; cytoplasm; plasma membrane; nucleusMolecular Function: protein binding; interleukin-1 receptor binding; zinc ion binding; thyroid hormone receptor binding; kinase bindingBiological Process: release of cytoplasmic sequestered NF-kappaB; focal adhesion formation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of cell migration
UniProt Protein Details:
NCBI Summary:	This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
UniProt Code:	Q15654
NCBI GenInfo Identifier:	20981729
NCBI Gene ID:	7205
NCBI Accession:	Q15654.3
UniProt Secondary Accession:	Q15654,O15170, O15275, Q9BTB2, Q9BUE5, Q9BXP3, Q9UNT4 A4D2E7, F2ZC07, F2ZC08
UniProt Related Accession:	Q15654
Molecular Weight:	476
NCBI Full Name:	Thyroid receptor-interacting protein 6
NCBI Synonym Full Names:	thyroid hormone receptor interactor 6
NCBI Official Symbol:	TRIP6
NCBI Official Synonym Symbols:	OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
NCBI Protein Information:	thyroid receptor-interacting protein 6; zyxin related protein 1; TR-interacting protein 6; OPA-interacting protein 1; thyroid hormone receptor interacting protein 6
UniProt Protein Name:	Thyroid receptor-interacting protein 6
UniProt Synonym Protein Names:	Opa-interacting protein 1; OIP-1; Zyxin-related protein 1; ZRP-1
Protein Family:	Thyroid receptor-interacting protein
UniProt Gene Name:	TRIP6
UniProt Entry Name:	TRIP6_HUMAN