TRIM74 Antibody (PACO17315)
- SKU:
- PACO17315
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TRIM74 Antibody (PACO17315) |
| Antibody SKU: | PACO17315 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:30-1:150 |
| Species Reactivity: | Human |
| Immunogen: | Full length fusion protein |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17315(TRIM74 Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | TRIM 74 (Tripartite motif-containing protein 74) is a possible protein coding regions found at gene location 7q11.23. Tripartite motif (TRIM) proteins play important roles in a variety of cellular functions including cell proliferation, differentiation, development, oncogenesis, and apoptosis. TRIM gene expression analysis in primary human immune cells seem to suggest the involvement of TRIM proteins in also regulating host antiviral activities. The gene encoding TRIM 74 maps to human chromosome 7, which houses over 1,000 genes and comprises nearly 5% of the human genome. Chromosome 7 has been linked to Osteogenesis imperfecta, Pendred syndrome, Lissencephaly, Citrullinemia and Shwachman-Diamond syndrome. The deletion of a portion of the q arm of chromosome 7 is associated with Williams-Beuren syndrome, a condition characterized by mild mental retardation, an unusual comfort and friendliness with strangers and an elfin appearance. Deletions of portions of the q arm of chromosome 7 are also seen in a number of myeloid disorders including cases of acute myelogenous leukemia and myelodysplasia. |
| Synonyms: | tripartite motif containing 74 |
| UniProt Protein Function: | TRIM74: Belongs to the TRIM/RBCC family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 7q11.23 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86UV6 |
| NCBI GenInfo Identifier: | 56404879 |
| NCBI Gene ID: | 378108 |
| NCBI Accession: | Q86UV6.1 |
| UniProt Secondary Accession: | Q86UV6,B7WP46 |
| UniProt Related Accession: | Q86UV6 |
| Molecular Weight: | 28,419 Da |
| NCBI Full Name: | Tripartite motif-containing protein 74 |
| NCBI Synonym Full Names: | tripartite motif containing 74 |
| NCBI Official Symbol: | TRIM74 |
| NCBI Official Synonym Symbols: | TRIM50C |
| NCBI Protein Information: | tripartite motif-containing protein 74 |
| UniProt Protein Name: | Tripartite motif-containing protein 74 |
| UniProt Synonym Protein Names: | Tripartite motif-containing protein 50C |
| Protein Family: | Tripartite motif-containing protein |
| UniProt Gene Name: | TRIM74 |
| UniProt Entry Name: | TRI74_HUMAN |
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