TRIM71 Antibody (PACO57164)
- SKU:
- PACO57164
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TRIM71 Antibody (PACO57164) |
| Antibody SKU: | PACO57164 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:500-1:1000 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human E3 ubiquitin-protein ligase TRIM71 protein (125-209AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | IHC image of PACO57164 diluted at 1:600 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
 | IHC image of PACO57164 diluted at 1:600 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
| Background: | E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1. |
| Synonyms: | E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71), TRIM71, LIN41 |
| UniProt Protein Function: | TRIM71: May be involved in controlling the timing of organ formation during development. Belongs to the TRIM/RBCC family.Chromosomal Location of Human Ortholog: 3p22.3Molecular Function: miRNA binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: neural tube development; protein autoubiquitination; fibroblast growth factor receptor signaling pathway; neural tube closure; miRNA-mediated gene silencing, negative regulation of translation; G1/S transition of mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q2Q1W2 |
| NCBI GenInfo Identifier: | 78068056 |
| NCBI Gene ID: | 131405 |
| NCBI Accession: | ABB18374.1 |
| UniProt Secondary Accession: | Q2Q1W2 |
| UniProt Related Accession: | Q2Q1W2 |
| Molecular Weight: | 93,385 Da |
| NCBI Full Name: | LIN41 |
| NCBI Synonym Full Names: | tripartite motif containing 71, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | TRIM71 |
| NCBI Official Synonym Symbols: | LIN41; LIN-41 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM71 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM71 |
| UniProt Synonym Protein Names: | Protein lin-41 homolog; Tripartite motif-containing protein 71 |
| Protein Family: | |
| UniProt Gene Name: | TRIM71 |
| UniProt Entry Name: | LIN41_HUMAN |
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