TRIM71 Antibody (PACO20703)
- SKU:
- PACO20703
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TRIM71 Antibody (PACO20703) |
| Antibody SKU: | PACO20703 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human TRIM71 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 6%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20703(TRIM71 Antibody) at dilution 1/300 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 20 seconds. |
| Background: | LIN-41, also called tripartite motif-containing 71 (TRIM71), which was first identified in Caenorhabditis elegans, is responsible for the timing of cell fate determination. By encoding microRNAs (miRNAs), the heterochronic genes let-7 and lin-4 downregulate the gene encoding LIN-41. The miRNAs bind to six complementary sites on the 3' untranslated region (UTR) of the LIN-41 gene. This downregulation positively regulates the timing of the expression of LIN-29, an adult specification transcription factor. |
| Synonyms: | tripartite motif containing 71, E3 ubiquitin protein ligase |
| UniProt Protein Function: | TRIM71: May be involved in controlling the timing of organ formation during development. Belongs to the TRIM/RBCC family.Chromosomal Location of Human Ortholog: 3p22.3Molecular Function: miRNA binding; zinc ion binding; ubiquitin-protein ligase activity; ligase activityBiological Process: neural tube development; protein autoubiquitination; fibroblast growth factor receptor signaling pathway; neural tube closure; miRNA-mediated gene silencing, negative regulation of translation; G1/S transition of mitotic cell cycle |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q2Q1W2 |
| NCBI GenInfo Identifier: | 78068056 |
| NCBI Gene ID: | 131405 |
| NCBI Accession: | ABB18374.1 |
| UniProt Secondary Accession: | Q2Q1W2 |
| UniProt Related Accession: | Q2Q1W2 |
| Molecular Weight: | 93,385 Da |
| NCBI Full Name: | LIN41 |
| NCBI Synonym Full Names: | tripartite motif containing 71, E3 ubiquitin protein ligase |
| NCBI Official Symbol: | TRIM71 |
| NCBI Official Synonym Symbols: | LIN41; LIN-41 |
| NCBI Protein Information: | E3 ubiquitin-protein ligase TRIM71 |
| UniProt Protein Name: | E3 ubiquitin-protein ligase TRIM71 |
| UniProt Synonym Protein Names: | Protein lin-41 homolog; Tripartite motif-containing protein 71 |
| Protein Family: | |
| UniProt Gene Name: | TRIM71 |
| UniProt Entry Name: | LIN41_HUMAN |
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