| UniProt Protein Function: | TRIM6: is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]Protein type: Ubiquitin conjugating systemChromosomal Location of Human Ortholog: 11p15.4Cellular Component: cytoplasmMolecular Function: protein binding; protein binding, bridging; protein kinase bindingBiological Process: negative regulation of viral genome replication; positive regulation of cytokine secretion during immune response; positive regulation of defense response to virus by host; positive regulation of peptidyl-serine phosphorylation; response to lipopolysaccharide |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010] |
| UniProt Code: | Q9C030 |
| NCBI GenInfo Identifier: | 25009488 |
| NCBI Gene ID: | 117854 |
| NCBI Accession: | Q9C030.1 |
| UniProt Secondary Accession: | Q9C030,Q86WZ8, Q9HCR1, A8K2A7, B4DDQ5 |
| UniProt Related Accession: | Q9C030 |
| Molecular Weight: | 36,400 Da |
| NCBI Full Name: | Tripartite motif-containing protein 6 |
| NCBI Synonym Full Names: | tripartite motif containing 6 |
| NCBI Official Symbol: | TRIM6 |
| NCBI Official Synonym Symbols: | RNF89 |
| NCBI Protein Information: | tripartite motif-containing protein 6 |
| UniProt Protein Name: | Tripartite motif-containing protein 6 |
| UniProt Synonym Protein Names: | RING finger protein 89 |
| Protein Family: | Tripartite motif-containing protein |
| UniProt Gene Name: | TRIM6 |
| UniProt Entry Name: | TRIM6_HUMAN |
