| UniProt Protein Function: | TRIM3: Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Belongs to the TRIM/RBCC family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 11p15.5 Cellular Component: cytoplasm; early endosome Molecular Function:protein C-terminus binding; protein binding; zinc ion binding; ubiquitin-protein ligase activity Biological Process: nervous system development; protein transport; protein ubiquitination |
| NCBI Summary: | The protein encoded by this gene is a member of the tripartite motif (TRIM) family, also called the 'RING-B-box-coiled-coil' (RBCC) subgroup of RING finger proteins. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to cytoplasmic filaments. It is similar to a rat protein which is a specific partner for the tail domain of myosin V, a class of myosins which are involved in the targeted transport of organelles. The rat protein can also interact with alpha-actinin-4. Thus it is suggested that this human protein may play a role in myosin V-mediated cargo transport. Alternatively spliced transcript variants encoding the same isoform have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O75382 |
| NCBI GenInfo Identifier: | 351721563 |
| NCBI Gene ID: | 10612 |
| NCBI Accession: | NP_001234935.1 |
| UniProt Secondary Accession: | O75382,Q4V9L4, Q9C038, Q9C039, B7Z5E6, F5H2Q8, |
| UniProt Related Accession: | O75382 |
| Molecular Weight: | 80,830 Da |
| NCBI Full Name: | tripartite motif-containing protein 3 isoform 1 |
| NCBI Synonym Full Names: | tripartite motif containing 3 |
| NCBI Official Symbol: | TRIM3 |
| NCBI Official Synonym Symbols: | BERP; HAC1; RNF22; RNF97 |
| NCBI Protein Information: | tripartite motif-containing protein 3; RING finger protein 97; ring finger protein 22; brain expressed ring finger; tripartite motif-containing 3; tripartite motif protein TRIM3; brain-expressed RING finger protein |
| UniProt Protein Name: | Tripartite motif-containing protein 3 |
| UniProt Synonym Protein Names: | Brain-expressed RING finger protein; RING finger protein 22; RING finger protein 97 |
| Protein Family: | Tripartite motif-containing protein |
| UniProt Gene Name: | TRIM3 |
| UniProt Entry Name: | TRIM3_HUMAN |
