Transgelin (TAGLN) Monoclonal Antibody
- SKU:
- CAB21209
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
- Applications:
- IF
Description
| Product Name: | Transgelin (TAGLN) Monoclonal Antibody |
| Product Code: | CAB21209 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Immunohistochemistry, Immunofluorescence |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC53169 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | IHC-P, IF/ICC, ELISA |
| Key Applications: | Immunohistochemistry, Immunofluorescence |
| Recommended Dilution: | IHC-P 1:50-1:200, IF/ICC 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Cellular Location: | Cytoplasm |
| Customer Validation: | IHC(Homo sapiens) |
This gene encodes a shape change and transformation sensitive actin-binding protein which belongs to the calponin family. It is ubiquitously expressed in vascular and visceral smooth muscle, and is an early marker of smooth muscle differentiation. The encoded protein is thought to be involved in calcium-independent smooth muscle contraction. It acts as a tumor suppressor, and the loss of its expression is an early event in cell transformation and the development of some tumors, coinciding with cellular plasticity. The encoded protein has a domain architecture consisting of an N-terminal calponin homology (CH) domain and a C-terminal calponin-like (CLIK) domain. Mice with a knockout of the orthologous gene are viable and fertile but their vascular smooth muscle cells exhibit alterations in the distribution of the actin filament and changes in cytoskeletal organization.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-201 of human Transgelin (TAGLN) (NP_003177.2). |
| Sequence: | MANKG PSYGM SREVQ SKIEK KYDEE LEERL VEWII VQCGP DVGRP DRGRL GFQVW LKNGV ILSKL VNSLY PDGSK PVKVP ENPPS MVFKQ MEQVA QFLKA AEDYG VIKTD MFQTV DLFEG KDMAA VQRTL MALGS LAVTK NDGHY RGDPN WFMKK AQEHK REFTE SQLQE GKHVI GLQMG SNRGA SQAGM TGYGR PRQII S |
| Synonyms: | SM22, SMCC, TAGLN1, WS3-10, SM22-alpha |
| Calculated MW: | 23kDa |
| Observed MW: | Refer to figures |
Related Products
Human Transgelin / TAGLN ELISA Kit
