TRAM2 Antibody (PACO35790)
- SKU:
- PACO35790
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TRAM2 Antibody (PACO35790) |
| Antibody SKU: | PACO35790 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Translocating chain-associated membrane protein 2 protein (316-370AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO35790 at dilution of 1:100. |
 | Immunofluorescent analysis of MCF-7 cells using PACO35790 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. |
| Synonyms: | Translocating chain-associated membrane protein 2, TRAM2, KIAA0057 |
| UniProt Protein Function: | TRAM2: Necessary for collagen type I synthesis. May couple the activity of the ER Ca(2+) pump SERCA2B with the activity of the translocon. This coupling may increase the local Ca(2+) concentration at the site of collagen synthesis, and a high Ca(2+) concentration may be necessary for the function of molecular chaperones involved in collagen folding. Belongs to the TRAM family.Protein type: Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 6p21.1-p12Cellular Component: integral to membraneMolecular Function: protein bindingBiological Process: protein transport; collagen biosynthetic process |
| UniProt Protein Details: | |
| NCBI Summary: | TRAM2 is a component of the translocon, a gated macromolecular channel that controls the posttranslational processing of nascent secretory and membrane proteins at the endoplasmic reticulum (ER) membrane.[supplied by OMIM, Jul 2004] |
| UniProt Code: | Q15035 |
| NCBI GenInfo Identifier: | 6912450 |
| NCBI Gene ID: | 9697 |
| NCBI Accession: | NP_036420.1 |
| UniProt Secondary Accession: | Q15035,A8K6T6 |
| UniProt Related Accession: | Q15035 |
| Molecular Weight: | 43,328 Da |
| NCBI Full Name: | translocating chain-associated membrane protein 2 |
| NCBI Synonym Full Names: | translocation associated membrane protein 2 |
| NCBI Official Symbol: | TRAM2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | translocating chain-associated membrane protein 2; TRAM-like protein |
| UniProt Protein Name: | Translocating chain-associated membrane protein 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Translocating chain-associated membrane protein |
| UniProt Gene Name: | TRAM2 |
| UniProt Entry Name: | TRAM2_HUMAN |
| Antibodies |
| TRAM2 Antibody (PACO12891) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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