TRAF4 Monoclonal Antibody
- SKU:
- CAB22472
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | TRAF4 Monoclonal Antibody |
| Product Code: | CAB22472 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Clone No: | ARC57454 |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:1000-1:5000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 0.05% BSA, 50% glycerol, pH7.3. |
| Positive Samples: | MCF7, HeLa, NIH/3T3, Rat thymus |
| Cellular Location: | Cell junction, Cell membrane, Cytoplasm, Cytoplasmic side, Nucleus, Peripheral membrane protein, cytoskeleton, perinuclear region, tight junction |
This gene encodes a member of the TNF receptor associated factor (TRAF) family. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. The encoded protein has been shown to interact with neurotrophin receptor, p75 (NTR/NTSR1), and negatively regulate NTR induced cell death and NF-kappa B activation. This protein has been found to bind to p47phox, a cytosolic regulatory factor included in a multi-protein complex known as NAD(P)H oxidase. This protein thus, is thought to be involved in the oxidative activation of MAPK8/JNK. Alternatively spliced transcript variants have been observed but the full-length nature of only one has been determined.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 209-470 of human TRAF4 (NP_004286.2). |
| Sequence: | SHQYQ CPRLP VACPN QCGVG TVARE DLPGH LKDSC NTALV LCPFK DSGCK HRCPK LAMAR HVEES VKPHL AMMCA LVSRQ RQELQ ELRRE LEELS VGSDG VLIWK IGSYG RRLQE AKAKP NLECF SPAFY THKYG YKLQV SAFLN GNGSG EGTHL SLYIR VLPGA FDNLL EWPFA RRVTF SLLDQ SDPGL AKPQH VTETF HPDPN WKNFQ KPGTW RGSLD ESSLG FGYPK FISHQ DIRKR NYVRD DAVFI RAAVE LPRKI LS |
| Synonyms: | CART1, MLN62, RNF83 |
| Calculated MW: | 54kDa |
| Observed MW: | 54kDa |
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