Tpt1 Antibody (PACO30762)
- SKU:
- PACO30762
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | Tpt1 Antibody (PACO30762) |
| Antibody SKU: | PACO30762 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:10-1:100 |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Translationally-controlled tumor protein (1-172AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO30762 at dilution of 1:20. |
| Background: | Involved in calcium binding and microtubule stabilization. |
| Synonyms: | Translationally-controlled tumor protein (TCTP) (21 kDa polypeptide) (p21) (p23), Tpt1, Trt |
| UniProt Protein Function: | TPT1: a novel heat shock protein with antiapoptotic and chaperone-like activity. Its levels are highly regulated in response to various cellular stimuli and stresses. Downregulated in response to proapoptotic treatments that induce Ca(++) stress, in a PKR-dependent manner. Colocalizes with CHFR to the mitotic spindle. Appears to be involved in calcium binding and microtubule stabilization. Its exosomal secretion is induced following DNA damage. Interacts with MCL1 and STEAP3, a p53-inducible transmembrane protein that facilitates the exosomal secretion of TPT1. Secreted TPT1 acts as a histamine-releasing factor, participates in inflammatory responses by inducing the release of histamine, and may play a role in tumor reversion. May play a direct role in placental calcium transport. Phosphorylation by Plk may decrease its microtubule-stabilizing activity and promote microtubule dynamics following metaphase. Critical for peripheral T cell maintenance and TCR-mediated cell proliferation.Protein type: Calcium-binding; Microtubule-bindingCellular Component: cytoplasm; extracellular space; multivesicular body; nucleoplasm; nucleus; tubulin complexMolecular Function: calcium ion binding; microtubule binding; transcription factor bindingBiological Process: cell differentiation; stem cell maintenance |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P63028 |
| NCBI GenInfo Identifier: | 6678437 |
| NCBI Gene ID: | 22070 |
| NCBI Accession: | NP_033455.1 |
| UniProt Secondary Accession: | P63028,P14701, Q3TMT0, Q3TWS8, Q3TWX0, Q3UAG7, Q569M9 |
| UniProt Related Accession: | P63028 |
| Molecular Weight: | 19,462 Da |
| NCBI Full Name: | translationally-controlled tumor protein |
| NCBI Synonym Full Names: | tumor protein, translationally-controlled 1 |
| NCBI Official Symbol: | Tpt1 |
| NCBI Official Synonym Symbols: | Trt; p21; p23; TCTP |
| NCBI Protein Information: | translationally-controlled tumor protein |
| UniProt Protein Name: | Translationally-controlled tumor protein |
| UniProt Synonym Protein Names: | 21 kDa polypeptide; p21; p23 |
| Protein Family: | Translationally-controlled tumor protein |
| UniProt Gene Name: | Tpt1 |
| UniProt Entry Name: | TCTP_MOUSE |
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