TP53INP2 Antibody (PACO23263)
- SKU:
- PACO23263
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TP53INP2 Antibody (PACO23263) |
| Antibody SKU: | PACO23263 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:50-1:100, IF:1:100-1:500 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthesized peptide derived from internal of human TP53INP2. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using TP53INP2 antibody. |
 | Immunofluorescence analysis of MCF-7 cells, using TP53INP2 antibody. |
| Background: | Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA. |
| Synonyms: | p53-inducible protein U; PIG-U; PINH; T53I2; tumor protein p53 inducible nuclear protein 2 |
| UniProt Protein Function: | TP53INP2: Dual regulator of transcription and autophagy. Positively regulates autophagy and is required for autophagosome formation and processing. May act as a scaffold protein that recruits MAP1LC3A, GABARAP and GABARAPL2 and brings them to the autophagosome membrane by interacting with VMP1 where, in cooperation with the BECN1-PI3-kinase class III complex, they trigger autophagosome development. Acts as a transcriptional activator of THRA.Cellular Component: cytoplasm; autophagic vacuole; cytoplasmic vesicle; cytosol; nucleusBiological Process: osteoblast differentiation; transcription, DNA-dependent; regulation of transcription, DNA-dependent; positive regulation of transcription, DNA-dependent; autophagy; positive regulation of autophagy; autophagic vacuole formation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q8CFU8 |
| NCBI GenInfo Identifier: | 30017443 |
| NCBI Gene ID: | 68728 |
| NCBI Accession: | NP_835212.1 |
| UniProt Secondary Accession: | Q8CFU8,Q3TDL6, Q711P5, Q8CHM4 |
| UniProt Related Accession: | Q8CFU8 |
| Molecular Weight: | 24,288 Da |
| NCBI Full Name: | tumor protein p53-inducible nuclear protein 2 |
| NCBI Synonym Full Names: | transformation related protein 53 inducible nuclear protein 2 |
| NCBI Official Symbol: | Trp53inp2 |
| NCBI Official Synonym Symbols: | Tp53inp2; 1110029F20Rik |
| NCBI Protein Information: | tumor protein p53-inducible nuclear protein 2; diabetes and obesity-regulated protein; tumor protein p53 inducible nuclear protein 2 |
| UniProt Protein Name: | Tumor protein p53-inducible nuclear protein 2 |
| UniProt Synonym Protein Names: | Diabetes and obesity-regulated protein |
| Protein Family: | Tumor protein p53-inducible nuclear protein |
| UniProt Gene Name: | Tp53inp2 |
| UniProt Entry Name: | T53I2_MOUSE |
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