TP53BP1 Polyclonal Antibody
- SKU:
- CAB21632
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
- Applications:
- IHC
Description
| Product Name: | TP53BP1 Polyclonal Antibody |
| Product Code: | CAB21632 |
| Reactivity: | Human, Mouse, Rat |
| Applications: | Western blotting, Immunohistochemistry |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human, Mouse, Rat |
| Tested Applications: | WB, IHC-P, ELISA |
| Key Applications: | Western blotting, Immunohistochemistry |
| Recommended Dilution: | WB 1:500-1:1000, IHC-P 1:50-1:200 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal, 50% glycerol, pH7.3. |
| Positive Samples: | Mouse brain, Rat uterus |
| Cellular Location: | Chromosome, Nucleus, centromere, kinetochore |
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 895-1031 of human TP53BP1 (NP_005648.1). |
| Sequence: | FCESS SETPF HFTLP KEGDI IPPLT GATPP LIGHL KLEPK RHSTP IGISN YPEST IATSD VMSES MVETH DPILG SGKGD SGAAP DVDDK LCLRM KLVSP ETEAS EESLQ FNLEK PATGE RKNGS TAVAE SVASP QK |
| Synonyms: | p202, 53BP1, TDRD30, p53BP1 |
| Calculated MW: | 214kDa |
| Observed MW: | 300-450kDa |
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