TOX3 Antibody (PACO46290)
- SKU:
- PACO46290
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TOX3 Antibody (PACO46290) |
| Antibody SKU: | PACO46290 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human TOX high mobility group box family member 3 protein (8-305AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: TOX3 antibody at 9 µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse spleen tissue. Lane 3: Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 63 kDa. Observed band size: 63, 24 kDa.. |
 | Immunofluorescent analysis of HepG2 cells using PACO46290 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human brain tissue using PACO46290 at dilution of 1:100. |
| Background: | Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. |
| Synonyms: | TOX high mobility group box family member 3 (CAG trinucleotide repeat-containing gene F9 protein) (Trinucleotide repeat-containing gene 9 protein), TOX3, CAGF9 TNRC9 |
| UniProt Protein Function: | TOX3: Transcriptional coactivator of the p300/CBP-mediated trancription complex. Activates transactivation through cAMP response element (CRE) sites. Protects against cell death by inducing antiapoptotic and repressing pro-apoptotic transcripts. Stimulates transcription from the estrogen-responsive or BCL-2 promoters. Required for depolarization-induced transcription activation of the C-FOS promoter in neurons. Associates with chromatin to the estrogen-responsive C3 promoter region. 2 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 16q12.1Molecular Function: chromatin binding; estrogen response element binding; phosphoprotein binding; protein binding; protein homodimerization activityBiological Process: negative regulation of neuron apoptosis; positive regulation of transcription, DNA-dependent |
| UniProt Protein Details: | |
| NCBI Summary: | The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009] |
| UniProt Code: | O15405 |
| NCBI GenInfo Identifier: | 146325793 |
| NCBI Gene ID: | 27324 |
| NCBI Accession: | O15405.2 |
| UniProt Secondary Accession: | O15405,B4DRD0, B5MCW4 |
| UniProt Related Accession: | O15405 |
| Molecular Weight: | 63,100 Da |
| NCBI Full Name: | TOX high mobility group box family member 3 |
| NCBI Synonym Full Names: | TOX high mobility group box family member 3 |
| NCBI Official Symbol: | TOX3 |
| NCBI Official Synonym Symbols: | CAGF9; TNRC9 |
| NCBI Protein Information: | TOX high mobility group box family member 3 |
| UniProt Protein Name: | TOX high mobility group box family member 3 |
| UniProt Synonym Protein Names: | CAG trinucleotide repeat-containing gene F9 protein; Trinucleotide repeat-containing gene 9 protein |
| Protein Family: | TOX high mobility group box family |
| UniProt Gene Name: | TOX3 |
| UniProt Entry Name: | TOX3_HUMAN |
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