TNRC6C Antibody (PACO48086)
- SKU:
- PACO48086
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TNRC6C Antibody (PACO48086) |
| Antibody SKU: | PACO48086 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Trinucleotide repeat-containing gene 6C protein (157-421AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Hela whole cell lysate. All lanes: TNRC6C antibody at 3.4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 176, 180 kDa. Observed band size: 176 kDa.. |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO48086 at dilution of 1:100. |
| Background: | Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. |
| Synonyms: | Trinucleotide repeat-containing gene 6C protein, TNRC6C, KIAA1582 |
| UniProt Protein Function: | Function: Plays a role in RNA-mediated gene silencing by micro-RNAs (miRNAs). Required for miRNA-dependent translational repression of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. Ref.8 Ref.11 Ref.12 Ref.13Subunit structure: Interacts with one or more of the argonaute family proteins AGO1, AGO2, AGO3 and AGO4. Interacts with PABPC1 and EIF4G1. Interacts with CNOT1; the interaction is direct and mediates the association with the CCR4-NOT complex. Interacts with PAN3; the interaction mediates the association with the PAN complex. Ref.7 Ref.8 Ref.9 Ref.11 Ref.12 Ref.13Domain: The silencing domain, also known as C-terminal effector domain (CED), can act in autonomous repression, including both translational inhibition and mRNA degradation.Sequence similarities: Belongs to the GW182 family.Contains 1 RRM (RNA recognition motif) domain.Contains 1 UBA domain.Sequence caution: The sequence BAB13408.2 differs from that shown. Reason: Erroneous initiation. The sequence BAB71179.1 differs from that shown. Reason: Erroneous initiation. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9HCJ0 |
| NCBI GenInfo Identifier: | 33413425 |
| NCBI Gene ID: | 57690 |
| NCBI Accession: | NP_061869 |
| UniProt Secondary Accession: | Q9HCJ0 |
| UniProt Related Accession: | Q9HCJ0 |
| Molecular Weight: | |
| NCBI Full Name: | trinucleotide repeat-containing gene 6C protein isoform 2 |
| NCBI Synonym Full Names: | trinucleotide repeat containing adaptor 6C |
| NCBI Official Symbol: | TNRC6C |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | trinucleotide repeat-containing gene 6C protein |
| UniProt Protein Name: | Trinucleotide repeat-containing gene 6C protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Trinucleotide repeat-containing gene 6C protein |
| UniProt Gene Name: | TNRC6C |
| UniProt Entry Name: | TNR6C_HUMAN |
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