TNRC6B Antibody (PACO57588)
- SKU:
- PACO57588
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TNRC6B Antibody (PACO57588) |
| Antibody SKU: | PACO57588 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| Species Reactivity: | Human |
| Immunogen: | Recombinant Human Trinucleotide repeat-containing gene 6B protein (639-779AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of A549 cells with PACO57588 at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| Background: | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. |
| Synonyms: | Trinucleotide repeat-containing gene 6B protein, TNRC6B, KIAA1093 |
| UniProt Protein Function: | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As scaffoldng protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q9UPQ9 |
| NCBI GenInfo Identifier: | 67782330 |
| NCBI Gene ID: | 23112 |
| NCBI Accession: | NP_001020014.1 |
| UniProt Secondary Accession: | Q9UPQ9,Q5TH52, Q8TBX2, B0QY73, B0QY78, B4DGC0 |
| UniProt Related Accession: | Q9UPQ9 |
| Molecular Weight: | |
| NCBI Full Name: | trinucleotide repeat-containing gene 6B protein isoform 3 |
| NCBI Synonym Full Names: | trinucleotide repeat containing 6B |
| NCBI Official Symbol: | TNRC6B |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | trinucleotide repeat-containing gene 6B protein |
| UniProt Protein Name: | Trinucleotide repeat-containing gene 6B protein |
| UniProt Synonym Protein Names: | |
| Protein Family: | Trinucleotide repeat-containing gene 6B protein |
| UniProt Gene Name: | TNRC6B |
| UniProt Entry Name: |
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