TNPO2 Antibody (PACO12839)
- SKU:
- PACO12839
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TNPO2 Antibody (PACO12839) |
| Antibody SKU: | PACO12839 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human TNPO2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Antigen Affinity purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | transportin 2;TNPO2;FLJ12155;IPO3;KPNB2B;TRN2 ; |
| UniProt Protein Function: | TNPO2: Probably functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Belongs to the importin beta family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Nuclear import; Karyopherin Chromosomal Location of Human Ortholog: 19p13.2 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; nuclear localization sequence binding; Ran GTPase binding Biological Process: intracellular protein transport |
| UniProt Code: | O14787 |
| NCBI GenInfo Identifier: | 209969836 |
| NCBI Gene ID: | 30000 |
| NCBI Accession: | NP_001129667.1 |
| UniProt Secondary Accession: | O14787,O14655, Q6IN77, |
| UniProt Related Accession: | O14787 |
| Molecular Weight: | 100,408 Da |
| NCBI Full Name: | transportin-2 isoform 2 |
| NCBI Synonym Full Names: | transportin 2 |
| NCBI Official Symbol: | TNPO2 |
| NCBI Official Synonym Symbols: | IPO3; TRN2; KPNB2B |
| NCBI Protein Information: | transportin-2; importin 3; karyopherin beta 2b, transportin; karyopherin beta-2b; transportin 2 (importin 3, karyopherin beta 2b) |
| UniProt Protein Name: | Transportin-2 |
| UniProt Synonym Protein Names: | Karyopherin beta-2b |
| Protein Family: | Transportin |
| UniProt Gene Name: | TNPO2 |
| UniProt Entry Name: | TNPO2_HUMAN |
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