TNK1 Polyclonal Antibody
- SKU:
- CAB21300
- Product Type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- WB
Description
| Product Name: | TNK1 Polyclonal Antibody |
| Product Code: | CAB21300 |
| Reactivity: | Human |
| Applications: | Western blotting |
| Host Species: | Rabbit |
| Purification Method: | Affinity purification |
| Isotype: | IgG |
| Reactivity: | Human |
| Tested Applications: | WB, ELISA |
| Key Applications: | Western blotting |
| Recommended Dilution: | WB 1:500-1:1000 |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3. |
| Positive Samples: | T-47D |
| Cellular Location: | Cytoplasm |
The protein encoded by this gene belongs to the tyrosine protein kinase family. Tyrosine protein kinases are important regulators of intracellular signal transduction pathways, mediating cellular proliferation, survival, and development. This gene is highly expressed in fetal tissues and at lower levels in few adult tissues, thus may function in signaling pathways utilized broadly during fetal development, and more selectively in adult tissues. It plays a negative regulatory role in the Ras-Raf1-MAPK pathway, and knockout mice have been shown to develop spontaneous tumors, suggesting a role as a tumor suppressor gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-380 of human TNK1 (NP_001238831.1). |
| Sequence: | LPEPE GGLKC LIPEG AVCRG ELLGS GCFGV VHRGL WTLPS GKSVP VAVKS LRVGP EGPMG TELGD FLREV SVMMN LEHPH VLRLH GLVLG QPLQM VMELA PLGSL HARLT APAPT PPLLV ALLCL FLRQL AGAMA YLGAR GLVHR DLATR NLLLA SPRTI KVADF GLVRP LGGAR GRYVM GGPRP IPYAW CAPES LRHGA FSSAS DVWMF GVTLW EMFSG GEEPW AGVPP YLILQ RLEDR ARLPR PPLCS RALYS LALRC WAPHP ADRPS FSHLE GLLQE A |
| Synonyms: | KOS1 |
| Calculated MW: | 72kDa |
| Observed MW: | 72kDa |
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