TNIP3 Antibody (PACO18506)
- SKU:
- PACO18506
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TNIP3 Antibody (PACO18506) |
| Antibody SKU: | PACO18506 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human TNIP3 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: PACO18506(TNIP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
| Background: | TNIP3, which called LIND, that was upregulated in monocytes infected with Listeria monocytogenes. The predicted 325-amino acid, protein contains 3 coiled-coil domains and is most likely localized to the nucleus. Binds to zinc finger protein TNFAIP3 and inhibits NF-kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13-acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding. |
| Synonyms: | TNFAIP3 interacting protein 3 |
| UniProt Protein Function: | TNIP3: Binds to zinc finger protein TNFAIP3 and inhibits NF- kappa-B activation induced by tumor necrosis factor, Toll-like receptor 4 (TLR4), interleukin-1 and 12-O-tetradecanoylphorbol-13- acetate. Overexpression inhibits NF-kappa-B-dependent gene expression in response to lipopolysaccharide at a level downstream of TRAF6 and upstream of IKBKB. NF-kappa-B inhibition is independent of TNFAIP3 binding.Protein type: InhibitorChromosomal Location of Human Ortholog: 4q27Molecular Function: polyubiquitin bindingBiological Process: MyD88-independent toll-like receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; inflammatory response; toll-like receptor 4 signaling pathway |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q96KP6 |
| NCBI GenInfo Identifier: | 192807305 |
| NCBI Gene ID: | 79931 |
| NCBI Accession: | NP_079149 |
| UniProt Secondary Accession: | Q96KP6,Q96PQ3, Q9H780, A1A574, A8K2Z4, B4DVF5, B4E023 |
| UniProt Related Accession: | Q96KP6 |
| Molecular Weight: | 44,886 Da |
| NCBI Full Name: | TNFAIP3-interacting protein 3 isoform 1 |
| NCBI Synonym Full Names: | TNFAIP3 interacting protein 3 |
| NCBI Official Symbol: | TNIP3 |
| NCBI Official Synonym Symbols: | LIND; ABIN-3 |
| NCBI Protein Information: | TNFAIP3-interacting protein 3; TNIP3 beta; ABIN-3 beta; Listeria induced; listeria-induced gene protein; TNFAIP3-interacting protein 3 beta; A20-binding inhibitor of NF-kappa-B activation 3 |
| UniProt Protein Name: | TNFAIP3-interacting protein 3 |
| UniProt Synonym Protein Names: | A20-binding inhibitor of NF-kappa-B activation 3; ABIN-3; Listeria-induced gene protein |
| Protein Family: | TNFAIP3-interacting protein |
| UniProt Gene Name: | TNIP3 |
| UniProt Entry Name: | TNIP3_HUMAN |
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