TMPRSS11F Antibody (PACO20716)
- SKU:
- PACO20716
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TMPRSS11F Antibody (PACO20716) |
| Antibody SKU: | PACO20716 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human TMPRSS11F |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using PACO20716(TMPRSS11F Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 8%SDS-PAGE, Lysate: 40 µg, Lane 1-3: Human thyroid tissue, Human esophagus cancer tissue, human normal rectum tissue, Primary antibody: PACO20716(TMPRSS11F Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20716(TMPRSS11F Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | TMPRSS11F is a type-II transmembrane protease, similar to hepsin (TMPRSS1). TMPRSS11F is a member of a larger family of membrane attached serine proteases, a poorly defined group that includes TMPRSS11A, B, C, D, E, F, Hepsin, Corin, Matriptase-1, 2 and 3. TMPRSS11F has a domain structure of an aminoterminal cytoplasmic domain, followed by a transmembrane domain, a SEA domain (Sea urchin sperm protein, Enterokinase, Agrin), a short spacer, then the trypsin-like serine protease domain. The SEA domain is thought to play a role in carbohydrate binding in the analogous protein sequences where it is found, but its role in TMPRSS11F is unclear. The cleavage of the Arg206-Ile207 bond is thought to liberate the catalytic domain. |
| Synonyms: | transmembrane protease, serine 11F |
| UniProt Protein Function: | TMPRSS11F: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Protease; Membrane protein, integralChromosomal Location of Human Ortholog: 4q13.2Cellular Component: integral to plasma membrane; extracellular regionMolecular Function: serine-type endopeptidase activityBiological Process: proteolysis |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6ZWK6 |
| NCBI GenInfo Identifier: | 194018492 |
| NCBI Gene ID: | 389208 |
| NCBI Accession: | NP_997290.2 |
| UniProt Secondary Accession: | Q6ZWK6,A8MXX2 |
| UniProt Related Accession: | Q6ZWK6 |
| Molecular Weight: | |
| NCBI Full Name: | transmembrane protease serine 11F |
| NCBI Synonym Full Names: | transmembrane protease, serine 11F |
| NCBI Official Symbol: | TMPRSS11F |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | transmembrane protease serine 11F; airway trypsin-like protease 4 |
| UniProt Protein Name: | Transmembrane protease serine 11F |
| UniProt Synonym Protein Names: | Airway trypsin-like protease 4 |
| Protein Family: | Transmembrane protease serine |
| UniProt Gene Name: | TMPRSS11F |
| UniProt Entry Name: | TM11F_HUMAN |
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