TMPRSS11B Antibody (PACO17286)
- SKU:
- PACO17286
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TMPRSS11B Antibody (PACO17286) |
| Antibody SKU: | PACO17286 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human TMPRSS11B |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO17286(TMPRSS11B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17286(TMPRSS11B Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | TMPRSS11B (transmembrane protease serine 11B), also known as airway trypsin-like protease 5, is a 416 amino acid, single-pass type II membrane protein that belongs to the peptidase S1 family and contains one peptidase S1 domain and one SEA domain. The gene that encodes TMPRSS11B consists of over 19,000 bases and maps to human chromosome 4q13.2. Chromosome 4 represents approximately 6% of the human genome and contains nearly 900 genes. Notably, the Huntingtin gene, which is found to encode an expanded glutamine tract in cases of Huntington's disease, is encoded by a gene that maps to chromosome 4. FGFR-3 is also encoded by a gene located on chromosome 4 and has been associated with thanatophoric dwarfism, achondroplasia, Muenke syndrome and bladder cancer. Chromosome 4 is also tied to Ellis-van Creveld syndrome, methylmalonic acid, mia and polycystic kidney disease. |
| Synonyms: | transmembrane protease, serine 11B |
| UniProt Protein Function: | TMPRSS11B: Probable serine protease. Belongs to the peptidase S1 family.Protein type: EC 3.4.21.-; Membrane protein, integral; ProteaseChromosomal Location of Human Ortholog: 4q13.2Cellular Component: plasma membraneMolecular Function: serine-type peptidase activity |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q86T26 |
| NCBI GenInfo Identifier: | 187761337 |
| NCBI Gene ID: | 132724 |
| NCBI Accession: | NP_872308.2 |
| UniProt Secondary Accession: | Q86T26,A8K4D9 |
| UniProt Related Accession: | Q86T26 |
| Molecular Weight: | 46,337 Da |
| NCBI Full Name: | transmembrane protease serine 11B |
| NCBI Synonym Full Names: | transmembrane protease, serine 11B |
| NCBI Official Symbol: | TMPRSS11B |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | transmembrane protease serine 11B |
| UniProt Protein Name: | Transmembrane protease serine 11B |
| UniProt Synonym Protein Names: | Airway trypsin-like protease 5 |
| Protein Family: | Transmembrane protease serine |
| UniProt Gene Name: | TMPRSS11B |
| UniProt Entry Name: | TM11B_HUMAN |
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