TMEM64 Antibody (PACO46286)
- SKU:
- PACO46286
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- Applications:
- WB
- Applications:
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
| Antibody Name: | TMEM64 Antibody (PACO46286) |
| Antibody SKU: | PACO46286 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Recombinant Human Transmembrane protein 64 protein (40-118AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: TMEM64 antibody at 8µg/ml + Mouse brain tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 40, 13, 15, 34 kDa. Observed band size: 40 kDa.. |
 | Immunohistochemistry of paraffin-embedded human lung tissue using PACO46286 at dilution of 1:100. |
| Background: | Positively regulates TNFSF11-induced osteoclast differentiation. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with SERCA2 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytosolic Ca (2+) spiking for activation of NFATC1 and production of mitochondrial ROS, thereby triggering Ca (2+) signaling cascades that promote osteoclast differentiation and activation. Negatively regulates osteoblast differentiation and positively regulates adipocyte differentiation via modulation of the canonical Wnt signaling pathway. Mediates the switch in lineage commitment to osteogenesis rather than to adipogenesis in mesenchymal stem cells by negatively regulating the expression, activity and nuclear localization of CTNNB1. |
| Synonyms: | Transmembrane protein 64, TMEM64 |
| UniProt Protein Function: | TMEM64: Belongs to the TVP38/TMEM64 family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8q21.3Biological Process: negative regulation of osteoblast differentiation; positive regulation of fat cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6YI46 |
| NCBI GenInfo Identifier: | 223555958 |
| NCBI Gene ID: | 169200 |
| NCBI Accession: | NP_001008495.2 |
| UniProt Secondary Accession: | Q6YI46,Q2HIZ7, Q8N3G6, B4DUC0, F5GXM4 |
| UniProt Related Accession: | Q6YI46 |
| Molecular Weight: | |
| NCBI Full Name: | transmembrane protein 64 isoform 1 |
| NCBI Synonym Full Names: | transmembrane protein 64 |
| NCBI Official Symbol: | TMEM64 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | transmembrane protein 64 |
| UniProt Protein Name: | Transmembrane protein 64 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Transmembrane protein |
| UniProt Gene Name: | TMEM64 |
| UniProt Entry Name: | TMM64_HUMAN |
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